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Quercetin increases the bioavailability of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in rats |
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| Authors: | Maaike E. Schutte Gerrit M. Alink Andreas P. Freidig Bert Spenkelink Judith C.H. Vaessen Johannes J.M. van de Sandt John P. Groten Ivonne M.C.M. Rietjens |
| Affiliation: | 1. Division of Toxicology, Wageningen University, P.O. Box 8000, 6700 EA Wageningen, The Netherlands;2. TNO Quality of Life, Biosciences Department, P.O. Box 360, 3700 AJ Zeist, The Netherlands;3. TNO Quality of Life, Food and Chemical Risk Analysis Department, P.O. Box 360, 3700 AJ Zeist, The Netherlands;4. Department of Toxicology and Drug Disposition, Schering-Plough, P.O. Box 20, 5340 BH Oss, The Netherlands;5. WU/TNO Center for Food Toxicology, P.O. Box 8000, 6700 EA Wageningen, The Netherlands |
| Abstract: | This study investigates whether the previous observation that quercetin increases the transport of PhIP through Caco-2 monolayers in vitro could be confirmed in an in vivo rat model. |
| Keywords: | ABC, ATP binding cassette BCRP, breast cancer resistance protein CYP, cytochrome P450 MDCK, Madin&ndash Darby Canine Kidney MRP, multidrug resistance protein P-gp, P-glycoprotein (MDR1) PhIP, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine SD, Sprague&ndash Dawley SEM, standard error of the mean |
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