| HDACs及HDAC3与胶质瘤的相关性研究进展 |
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| 引用本文： | 朱晋,;姜涛,;万虹,;张玉琪.HDACs及HDAC3与胶质瘤的相关性研究进展[J].医学综述,2014(24):4469-4471. |
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| 作者姓名： | 朱晋 ;姜涛 ;万虹 ;张玉琪 |
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| 作者单位： | [1]首都医科大学附属北京天坛医院神经外科,北京100050; [2]北京市神经外科研究所,北京100050; [3]清华大学玉泉医院神经外科,北京100049 |
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| 摘 要： | 胶质瘤是常见的中枢神经系统肿瘤,组蛋白去乙酰化酶(HDACs)是最新发现的一系列致癌因子,在很多实体肿瘤中发挥重要作用,在脑胶质瘤中也不例外。其中的HDAC3是最近研究的热点,国内外很多学者发现其在人类肿瘤中起到了致癌的作用。人们应用抑制剂减弱HDAC3的表达后,人脑胶质瘤细胞的生长、侵袭等能力出现明显减弱。这就为肿瘤治疗提供了一条新途径。
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| 关 键 词： | 胶质瘤 组蛋白去乙酰化酶 组蛋白去乙酰化酶3 |
Research Progress on the Correlation of HDACs and HDAC3 with Glioma |
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| Institution: | ZHU Jin, JIANG Tao, WAN Hong, ZHANG Yu-qi( 1. Department of Neurosurgery, Beijing Tiantan Hospital Affiliated to Capital Medical University, Beijing 100050, China; 2. Beefing Institute of Neurosurgery, Beijing 100050, China; 3. Department of Neurosurgery , Yuquan Hospital Affiliated to Tsinghua University, Beijing 100049, China) |
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| Abstract: | Glioma is a common tumor in central nervous system. Histone deacetylases （HDACs） are a series of newly discovered carcinogenic factors, which play an important role in many solid tumors, including gliomas. Histone deacetylase 3 （ HDAC3 ） has become a focus in recent research, many scholars worldwide have found that it plays a role of carcinogenesis in human tumors. After the expression of HDAC3 is reduced by the inhihitors,the growth and invasive ability of human glioma cell appears significantly weakened, which provides a new way for the cancer treatment. |
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| Keywords: | Glioma Histone deacetylase Histone deacetylase 3 |
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