吸烟对血小板体积和膜流动性的影响及机制研究进展

吸烟可引起血脂代谢异常,机体氧化应激增加,抗氧化能力下降,降低一氧化氮生物利用度,还可直接破坏血管内皮,刺激血小板活化,最终导致平均血小板体积增加,血小板膜流动性减低,从而增加血栓形成的风险。吸烟有关的血栓性疾病的发病机制之一就是吸烟对血小板体积和膜流动性的影响。因此,吸烟可作为预测血栓性疾病的危险因子之一。该文就吸烟影响血小板体积和膜流动性的机制予以综述。

Research Progress in the Effect of Smoking on Platelet Volume and Membrane Fluidity and Its Mechanisms

Smoking can cause abnormalities to blood lipid metabolism, increased oxidative stress to the body,decreased antioxidant ability and hioavailability of nitric oxide. It can directly damage the vascular endothelium, and further activate platelets, resulting in the increase of average platelet volume and decrease of platelet membrane fluidity（PMF）, which may increase the risk of thrombosis. One of the pathogenesis of thrombotic diseases is the influence of smoking on platelet volumn and membrane fluidity. Therefore, smoking can be a risk factor for the prediction of thrombotic diseases. Here is to make a review of the mechanism of how smoking affects platelet volume and membrane fluidity.