慢性牙周炎患者唾液中miR-1246的表达及其临床意义

目的 探讨慢性牙周炎(CP)患者唾液中miR-1246的表达及其临床意义.方法 选取2017年1月～2019年5月保定市第二中心医院收治的94例CP患者作为CP组和50例体检正常者作为对照组.CP患者分为轻度牙周炎组(n=23),中度牙周炎组(n=37)和重度牙周炎组(n=35),检测各组唾液中miR-1246的表达水...

Expression of miR-1246 in Saliva of Patients with Chronic Periodontitis and Its Clinical Significance

Objective To investigate the expression of miR-1246 in saliva of patients with chronic periodontitis(CP)and its clinical significance.Methods 94 CP patients admitted to the Second Central Hospital of Baoding City from January 2017 to May 2019 were selected as the CP group and 50 normal patients as the control group.Patients with CP were divided into mild periodontitis group(n=23),moderate periodontitis group(n=37)and severe periodontitis group(n=35).The expression level of miR-1246 in saliva of each group was detected.The CP patients were treated with periodontal basic therapy,and the expression level of miR-1246 in saliva of the patients before and after treatment was detected respectively,and the periodontal clinical indicators of depth of exploration(PD),loss of attachment(AL),plaque index(PLI)and bleeding index(BI)were examined.Pearson correlation were used to analyze the correlation between the expression of miR-1246 and PD,AL,PLI and BI in patients with CP.Results The expression level of miR-1246 in saliva of CP group was significantly higher than that of control group(7.28±2.56 vs 3.52±1.14,t=16.294,P<0.01).The expression level of miR-1246 in saliva of severe group(10.47±3.38 vs 7.38±2.70,4.24±1.30)were significantly higher than that of moderate group and mild group,the difference was statistically significant(t=13.516,21.482,all P<0.01).The expression level of miR-1246 in saliva of CP patients after treatment(4.75±1.61 vs 7.28±2.56)was significantly lower than that before treatment,the difference was statistically significant(t=10.490,P<0.01).After treatment,PD(2.84±0.72mm vs 5.16±1.30 mm),AL(3.08±0.64mm vs 5.62±1.15 mm),PLI(1.13±0.28 vs 2.62±0.41)and BI(2.95±0.58 vs 1.64±0.47)in CP patients were significantly lower than those before treatment,the difference was statistically significant(r=8.742~10.873,all P<0.01).The correlation analysis showed that the expression level of miR-1246 was positively correlated with PD,AL,PLI and BI in CP patients before and after treatment(r=0.592~0.874,all P<0.01).Conclusion The expression level of miR-1246 in the saliva of CP patients was significantly increased and decreased significantly after treatment.The expression level of miR-1246 was closely related to the severity of CP and clinical indicators of periodontitis,which was expected to provide a new idea for the prevention and treatment of CP.