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The α4β1 integrin in sickle cell disease |
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| Authors: | J.E. Brittain L.V. Parise |
| Affiliation: | aDepartment of Biochemistry and Biophysics, School of Medicine, University of North Carolina at Chapel Hill, CB 7260, Chapel Hill, NC 27599, USA;bCarolina Cardiovascular Biology Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA |
| Abstract: | The α4β1 integrin is an adhesion receptor expressed on reticulocytes in sickle cell disease (SCD) and mediates the adhesion of these cells to sub-endothelial matrix proteins and the endothelium. In this review, we describe the mechanism of activation of the α4β1 integrin on sickle reticulocytes and discuss novel roles for this integrin in SCD as a result of this activation. We also illustrate novel therapies in SCD that may target the integrin and alleviate vaso-occlusion. |
| Keywords: | α 4β 1 integrin activation Sickle cell disease Adhesion molecules Vaso-occlusionMots clé s: Activation de l’ inté grine α 4β 1 Dré panocytose Molecules d’ adhé rence Vaso-occlusion |
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