| 刺五加注射液对人肺腺癌A549细胞增殖的抑制作用 |
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| 引用本文： | 靳祎,王恩军,朱宝成. 刺五加注射液对人肺腺癌A549细胞增殖的抑制作用[J]. 军医进修学院学报, 2009, 30(5): 729-730 |
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| 作者姓名： | 靳祎 王恩军 朱宝成 |
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| 作者单位： | 1. 河北大学医学部,河北保定,071000
2. 河北农业大学,生命科学学院,河北保定,071001 |
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| 摘 要： | 目的探讨刺五加注射液对人肺腺癌A549细胞的体外增殖的抑制作用。方法采用MTT法测定了不同浓度的刺五加注射液对人肺腺癌A549细胞的体外抑制作用，倒置显微镜观察细胞形态变化。结果刺五加注射液浓度越高对A549细胞抑制作用越好，作用时间越长抑制效果越强，量效关系和时效关系良好；形态学观察到细胞凋亡。结论刺五加注射液对人肺腺癌A549细胞的增殖有较强的抑制作用。
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| 关 键 词： | 刺五加属 肺肿瘤 细胞增殖 基因,肿瘤抑制 |
Inhibitory effect of Acanthopanax senticosus injection on growth of human lung adenocarcinoma A549 cells |
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| JIN Yi,WANG En-jun,ZHU Bao-cheng. Inhibitory effect of Acanthopanax senticosus injection on growth of human lung adenocarcinoma A549 cells[J]. Academic Journal of Pla Postgraduate Medical School, 2009, 30(5): 729-730 |
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| Authors: | JIN Yi WANG En-jun ZHU Bao-cheng |
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| Affiliation: | JIN Yi, WANG En-jun , ZHU Bao-cheng (1.Medical Department of Hebei University, Baoding 071000, China; 2.Academy of Life Sciences, Hebei Agricultural University, Baoding 071001, China) |
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| Abstract: | Objective To explore the inhibitory effect of Acanthopanax senticosus injection on the growth of human lung adenoearcinoma A549 ceils. Methods MTT assay was used to determine the growth of lung adenocarcinoma 3-549 ceils and inhibitory rates of Acanthopanax senticosus injection at different concentrations, and to observe the change in cell shape under an inverted microscope. Results Acanthopanax sentieosus injection at a higher concentration had a stronger inhibitory effect on the growth of human lung adenocarcinoma A549 cells, longer action time, and a better dose-effect and time-effect relation. Apoptosis of human lung adenocarcinoma A549 cells was found during morphological observations. Conclusion Acanthopanax senticosus injection has a stronger inhibitory effect on the growth of human lung adenoearcinoma A549 cells. |
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| Keywords: | acanthopanax lung neoplasms cell proliferation genes, tumor suppressor |
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