| 细胞表面热休克蛋白90与肿瘤转移 |
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| 引用本文： | 郭常安. 细胞表面热休克蛋白90与肿瘤转移[J]. 国际肿瘤学杂志, 2010, 37(3). DOI: 10.3760/cma.j.issn.1673-422X.2010.03.010 |
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| 作者姓名： | 郭常安 |
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| 作者单位： | 复旦大学附属中山医院骨科,上海,200032 |
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| 基金项目： | 教育部留学回国人员科研启动基金 |
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| 摘 要： | 热休克蛋白90(Hsp90)调控其多种底物蛋白的稳定及功能,是抗肿瘤治疗的独特靶蛋白.Hsp90不仅位于细胞表面,甚至分泌至细胞外发挥一定功能,且与肿瘤高侵袭性及转移密切相关.
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| 关 键 词： | HSP90热休克蛋白质类 肿瘤转移 |
Cell surface heat shock protein 90 and tumor metastasis |
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| GUO Chang-an. Cell surface heat shock protein 90 and tumor metastasis[J]. Journal of International Oncology, 2010, 37(3). DOI: 10.3760/cma.j.issn.1673-422X.2010.03.010 |
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| Authors: | GUO Chang-an |
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| Abstract: | Heat shock protein 90(Hsp90)is one of the most abundant molecular chaperones whose association is essential to maintain the stability and function of uumerous client proteins,and is the unique target protein for cancer therapy.Over the past years,most attention has been given to the study of the intracelhilar Hsp90.However,a pool of Hsp90 has been described to be present on the cell surface and even to be secreted extracellularly,which plays an important role in modulating cancer cell invasion in vitro and metastasis in vivo. |
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| Keywords: | HSP90 heat-shock proteins Neoplasm metastasis |
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