Bone induction by composite of bioerodible polyorthoester and demineralized bone matrix in rats

A composite of a local, sustained, drug-release system, Alzamer® bioerodible polyorthoester, and demineralized bone-matrix (DBM) particles implanted in the abdominal muscle of 89 Wistar rats induced cartilage and bone formation at the same rate as DBM when evaluated histologically and by ⁸⁵Sr uptake. the composite implant was technically easier to use than DBM alone.