IgE Multiple Myeloma: A Report of the Third Case

The third known case of IgE multiplemyeloma is described. The patient wasa 65-yr-old woman who died 11 moafter a diagnosis of multiple myelomawas made by a surgical biopsy of theleft iliac crest. Her serum containedapproximately 2.7 g/100 ml of a paraprotein of mid- mobility. The isolatedanomalous protein gave a reaction ofidentity with the IgE myeloma proteinof the second reported case when reacted with a specific IgE antiserum.The light-chain type of the myelomaprotein was in contrast to of theother two IgE myeloma proteins. Herclinical manifestations differed fromthe two previously reported cases inseveral respects. She had neitherplasma cell leukemia nor overt BenceJones proteinuria and developed rapidly progressive widespread osteosclerotic lesions that were associated withbone pain.

Submitted on June 7, 1971 Revised on August 9, 1971 Accepted on September 1, 1971