湛江地区3677例乳腺癌的临床分析

目的分析湛江地区近20年来3677例乳腺癌临床流行病学特征的变化情况，探讨其变化规律及可能的发展趋势。方法总结分析湛江地区广东医学院附属医院等四家医院1992～2011年经病理确诊为乳腺癌的3677例资料，将20年资料按每5年为一时间段进行统计学分析。结果1992～1996年与2007～2011年比较，乳腺癌的收治率增加了193：4％。发病中位年龄由49岁降至46岁，下降了3岁；〈30年龄组比例由2．31％升至4．86％，30～39岁年龄组由14，81％升至17．95％；而左侧乳腺癌从55．56％降至50．44％（x2=6．04，P〈0．05），乳腺癌的乡村患者比例从26．39％上升至42．22％（X2=46．01，P〈0．01）；早期浸润性癌的比例11．42％升至14．45％。结论近20年来湛江地区乳腺癌的发病趋势复杂化。乳腺癌可能有发病率上升、发病年龄降低的趋势，应加强居民的健康教育，提高疾病预防意识。

Clinical analysis of 3677 patients.with breast cancer in Zhanjiang area

Objective To analyze and predict the trends in the clinical characteristics of 3677 breast cancer patients during the past twenty years in Zhanjiang. Methods The clinical data of 3677 patients with breast cancer confirmed pathologically were analyzed. These patients were hospitalized to affiliated hospital of Guangdong Medical College and other three hospitals in Zhanjiang, 1992-2011 were divided into four 5-year groups. Results The hospitalization num- ber of breast cancer in the 2007-2011 5-year period was 193.4%. which was higher than that of the 1992-1996 pe- riod with an annual increase of 9.67%. The median age of patients in 2007-20ll was 49 years. Which was 3 years lower than that in 1992-1996. the proportion of breast cancer in 〈30 years age group was 4.86%in 2007-2011, which was higher than that in 1992-1996 （2.31%）. And the cancer in 30~39 years age group increased from 14.81% to 17.95%. the proportion of early invasive carcinoma was was 14.45% in 2007-2011, which was higher than that in 1992-1996 （11.42%）. The left breast cancer dropped from 55.56% to 50.44% （x=6.04, P 〈 0.05）. The proportion of patients in rural 2007-2011 was 42.22% ,which was higher than that in 1992-1996 （26.39%）（X2=46.01, P 〈 0.01）. Conclusion The trends in the clinical characteristics of breast cancer during the past twenty years are more complex. The incidence of breast cancer may have an increasing tendency and the age of breast cancer may have an reducing tendency in the western region of Guangdong province. Thus healthy education and colorectal cancer prevention should be strengthened.