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Assessment of Proliferative Activity of Glandular Cells in Hyperfunctioning Parathyroid Gland Using Flow Cytometric and Immunohistochemical Methods |
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| Authors: | Pan Xiao-Lin Naohiko Koide Shinya Kobayashi Masaru Kobayashi Akira Sugenoya Futoshi Iida Tsutomu Katsuyama Nobuteru Usuda Tetsuji Nagata |
| Affiliation: | (1) Department of Surgery, Shishu University School of Medicine, Asahi 3-1-1, Matsumoto 390, Japan, JP;(2) Department of Clinical Laboratory, Shinshu University School of Medicine, Asahi 3-1-1, Matsumoto 390, Japan, JP;(3) Department of Anatomy and Cell Biology, Shinshu University School of Medicine, Asahi 3-1-1, Matsumoto 390, Japan, JP |
| Abstract: | p < 0.001). The %SPF determined by flow cytometry was consistently higher than both the BrdU LI and the Ki-67 LI. This discrepancy cannot be explained precisely, and further improvements are required for the flow cytometric analysis of %SPF. The cell cycle study by BrdU and Ki-67 immunohistochemistry suggested that the glandular cells of the hyperfunctioning parathyroid were characterized by low proliferative activity. No evidence of rapid cell turnover rate assumed from the flow cytometric study could be observed in the hyperfunctioning parathyroid gland. |
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