| 雌激素及其膜性受体G蛋白偶联雌激素受体在糖脂代谢中的研究进展 |
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| 引用本文： | 冯小静,汪晨扬,伍静.雌激素及其膜性受体G蛋白偶联雌激素受体在糖脂代谢中的研究进展[J].中华老年医学杂志,2021(3):393-396. |
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| 作者姓名： | 冯小静 汪晨扬 伍静 |
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| 作者单位： | 华中科技大学同济医学院附属协和医院麻醉科 |
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| 基金项目： | 国家自然科学基金项目(81772131)。 |
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| 摘 要： | G蛋白偶联雌激素受体(GPER)作为一种新发现的雌激素膜蛋白偶联受体,近年来在内分泌代谢研究中广受关注.GPER介导的糖脂代谢异常和炎症反应失衡是多种内分泌代谢疾病发生发展的病生机制之一,有望成为治疗冠状动脉粥样硬化、肥胖和糖尿病的新药物靶标.本文从糖脂代谢和炎症几方面简要综述了GPER介导的雌激素通路的相关进展.
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| 关 键 词： | 受体 雌激素 代谢 炎症 |
The role of estrogen and its membrane receptor G protein-coupled estrogen pathway in regulating glucose and lipid metabolism and imbalance of inflammatory response:The latest research progress |
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| Feng Xiaojing,Wang Chenyang,Wu Jing.The role of estrogen and its membrane receptor G protein-coupled estrogen pathway in regulating glucose and lipid metabolism and imbalance of inflammatory response:The latest research progress[J].Chinese Journal of Geriatrics,2021(3):393-396. |
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| Authors: | Feng Xiaojing Wang Chenyang Wu Jing |
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| Institution: | (Department of Anesthesiology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China) |
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| Abstract: | G protein-coupled estrogen receptor(GPER),as a newly discovered estrogen membrane protein-coupled receptor,has attracted much attention in endocrine metabolism research in recent years.Abnormal glucose and lipid metabolism and imbalance of inflammatory response mediated by GPER is one of the pathogenesis mechanisms of various endocrine and metabolic diseases.GPER is expected to become a new drug target for the treatment of coronary atherosclerosis,obesity and diabetes.This article briefly reviews the progress of GPER-mediated estrogen signaling pathway in terms of glucose metabolism,lipid metabolism and inflammation. |
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| Keywords: | Receptors estrogen Metabolism Inflammation |
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