尘肺病患者外周血维生素D与淋巴细胞亚群、炎症因子的相关性研究

目的 了解尘肺病患者的维生素D水平,并分析维生素D与炎症因子、淋巴细胞亚群各指标之间的相关性.方法 选取60名老年男性健康体检人员为对照组,182名尘肺病患者为研究组,比较两组的维生素D水平;同时分析研究组维生素D水平、尘肺病期别与炎症因子、淋巴细胞亚群的相关性.结果 182名尘肺病患者维生素D缺乏人员的占比高于对照组...

Correlations between vitamin D and inflammatory factors and lymphocyte subpopulation in patients with pneumoconiosis

Objective To understand the vitamin D concentration of pneumoconiosis patients and its correlation with inflammatory factors and lymphocyte subpopulation. Methods Totally 182 pneumoconiosis patients and 60 elderly male healthy persons were studied. The vitamin D levels of the two groups were compared. The correlation of vitamin D level with pneumoconiosis stage,inflammatory factors,and lymphocyte subsets in the study group was analyzed. Results The proportion of vitamin D deficiency in 182 pneumoconiosis patients was higher than that in the control group(P < 0.05).The average level of 25(OH)D in study group was(21.55 ± 9.51)ng/mL,significantly lower than that in the control group[(27.16 ± 8.12)ng/mL](P < 0.01). The level of inflammatory factors,including IL-2 R,IL-6,IL-8,PCT and CRP increased gradually with the increment of pneumoconiosis stage(P < 0.05). IL-6 was the lowest in vitamin D sufficient group(P < 0.05),and IL-8,PCT and CRP decreased with the increase of 25(OH)D level(P < 0.05). The ratio of CD4/CD8 in patients with stage I pneumoconiosis was higher than that in patients with stage 2 and stage 3 pneumoconiosis(P <0.05);CD4+T cells and L/CD45 decreased with the increase of pneumoconiosis stage(P < 0.05). With the increase of25(OH)D level,the ratio of CD4+T cells and L/CD45 increased gradually,while CD8+T cells decreased gradually. There was a weak negative correlation between 25(OH)D and CRP level(r =-0.191,P < 0.05),and a weak positive correlation of 25(OH)D with IL-10,CD4/CD8 ratio,and L/CD45(r = 0.299,0.176,0.257,P < 0.05,respectively). Conclusions Vitamin D deficiency or insufficient was common in pneumoconiosis patients. Vitamin D may be involved in inflammation and immune functions by regulating inflammatory factors and lymphocyte subpopulation.