右美托咪定滴鼻给药用于听力障碍儿童术前镇静的效果

目的 观察不同剂量右美托咪定(Dex)滴鼻给药对听力障碍儿童术前镇静效果的影响.方法 选择年龄6个月～6岁拟行人工耳蜗植入术患儿80例,随机均分为4组.D1、D2、D3组分别给予Dex0.5、1.0、1.5 μg·kg-1滴鼻给药,对照组(C组)给予5％葡萄糖注射液0.2 mL.给药40 min后进入手术室,各组麻醉诱...

Preoperative sedation effects of intranasal dexmedetomidine in hearing disorder children

AIM To observe the preoperative sedative effects of different dose of intranasal dexmedetomidine(Dex)in hearing disorder children.METHODS Eligible 80 hearing disorder children,aged 6 months to 6 years,scheduled for cochlear implantation,were enrolled.The children were randomly divided into 4 groups equally to receive intranasal dexmedetomidine 0.5μg·kg^-1(group D1),1.0μg·kg^-1(group D2),1.5μg·kg^-1(group D3),or 5%glucose solution 0.2 mL(group C).Forty minutes after administration,children entered the operation room.The induction and maintenance of anesthesia was in the same way in each group.The modified Yale preoperative anxiety scale(m-YPAS)score at operation waiting area,pre-and 24 h postoperative,the sedation and behavior status score at parent-child separation before surgery,the pediatric anesthesia emergence delirium(PAED)score,and the heart rate(HR),blood pressure(BP),and pulse oxygen saturation(SpO2)of the children were recorded.RESULTS Preoperative sedation and behavior status score and PAED score of the group D2 and D3 were significantly lower than those of the group D1 and group C(P<0.05).The m-YPAS score at 24 h postoperative in the group Dex was significantly lower compared with the group C(P<0.05).In the group Dex,there was no significant change in HR and SpO2 after administration.The HR in the group Dex was significantly lower than that in the group C within 35 min after anesthesia induced(P<0.05).There were no adverse reactions such as hypoxia,hypotension,hypertension,nasal irritation,anaphylaxis,postoperative nausea and vomiting occurred during perioperative period.CONCLUSION Intranasal dexmedetomidine 1.0μg·kg^-1 could achieve satisfactory preoperative sedative effect and reduce the degree of emergence delirium and 24 h postoperative anxiety for hearing disorder children.