白细胞介素-2在胆囊胆固醇结石形成中的作用

①目的　探讨胆囊胆汁和胆囊组织中白细胞介素 2在胆囊胆固醇结石形成中的作用。②方法　采用放射免疫分析 (RIA)方法分别测定了 56例胆囊胆固醇结石及 1 6例非胆囊结石病人胆囊组织和胆汁中白细胞介素 2的含量。③结果　胆囊胆固醇结石组胆囊组织和胆囊胆汁中白细胞介素 2含量与对照组比较有显著性差异(F =6 .0 4、3 .84,q =3 .1 4～ 4 .78,P <0 .0 5、0 .0 1 ) ,且胆囊胆固醇结石组胆囊组织中白细胞介素 2含量与胆囊胆汁中的白细胞介素 2含量呈显著正相关关系 (r=0 .66 ,P <0 .0 0 1 )。多发结石组胆囊胆汁及胆囊组织中白细胞介素 2含量与单发结石组比较无显著性差异 (q =0 .74、0 .1 6 ,P >0 .0 5)。④结论　胆囊组织及胆囊胆汁中白细胞介素 2与胆囊胆固醇结石的形成密切相关 ,并在胆囊胆固醇结石的形成过程中起重要作用

A STUDY OF THE EFFECT OF INTERLEUKIN-2 ON CHOLESTEROL GALLSTONE FORMATION

Objective To investigate the role of interleukin 2(IL 2) in the formation of cholesterol gallstone. Methods A radioimmunoassay was used to detect the content of IL 2 in cholesterol gallstones in 56 patients and in the gall tissues and in bile in 16 non gallstone patients. Results The content of IL 2 in the gallbladder tissue and gallbladder bile in the cholesterol gallstone group showed great difference as compared with the control group ( F=6.04, 3.84, q=3.14-4.78, P <0.05, 0.01). In cholesterol gallstone group, IL 2 content in gallbladder tissue and in gallbladder bile showed significantly positive correlativity ( r= 0.66, P <0.001). IL 2 content in the bile and gallbladder tissues in multiple stone patients was higher than those single stone ones, though there was no significant difference ( q=0.74, 0.16, P >0.05). Conclusion IL 2 content in gallbladder tissue and gallbladder bile may take an important role in the formation of cholesterol gallstone.