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| HPLC法测定溶栓颗粒中阿魏酸的含量 | |
| 引用本文： | 石嫱,王焕芸. HPLC法测定溶栓颗粒中阿魏酸的含量[J]. 武警医学院学报, 2010, 19(7): 533-534,537 |
| 作者姓名： | 石嫱 王焕芸 |
| 作者单位： | 1. 武警内蒙古总队医院药剂科,内蒙古,呼和浩特,010040 2. 内蒙古医学院药学院,内蒙古,呼和浩特,010020 |
| 摘 要： | [目的]采用高效液相色谱法测定溶栓颗粒中阿魏酸的含量.[方法]采用C18色谱柱Kromasil 5 μ100A（250 mmx4.6mm,5μm）;流动相：甲醇：5%醋酸溶液（24：76）;流速：1.0ml/min;柱温：25℃;检测波长：323 nm.[结果]阿魏酸在3.02～18.12 μg/ml范围内呈良好线形关系,r=0.9999,（n=6）,平均加样回收率为100.2%,RSD=1.2%（n=6）.[结论]该法可作为溶栓颗粒的质量控制方法. |
| 关 键 词： | 溶栓颗粒 阿魏酸 高效液相色谱法 含量测定 |
Determination of ferulic acid in Rongshuan grannule by HPLC |
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| SHI Qiang,WANG Huan-yun. Determination of ferulic acid in Rongshuan grannule by HPLC[J]. Acta Academiae Medicinae CPAPF, 2010, 19(7): 533-534,537 | |
| Authors: | SHI Qiang WANG Huan-yun |
| Affiliation: | ( Department of Pharmacy, Inner Mongolia Autonomous Region Corps Hospital of Chinese People＇s Armed Police Force, Hohhot 010031,China) |
| Abstract: | [Objective] To establish a HPLC method for the determination of ferulic acid in Rongshuan grannule. [Methods] The chromatographic conditions included Kromasil 5 μ 100A C18 column（250 mm × 4.6 mm, 5 μ m） and mobile phase consisting of methyl alcohol：5% acetic acid （24：76）. The flow rate was 1.0 ml/min,column temperature was at 25℃ ; detection wavelength was 323 nm. [Results] The calibration curve was linear in the range of 3.02-18.12 μ g/ml for ferulic acid, r=0.9999, （n = 6） ; the average recovery was 100.2, and RSD was 1.2% （n = 6）. [ Conclusions ]This method is available for the quality control of Rongshuan grannule. |
| Keywords: | Rongshuan grannule Ferulic acid HPLC Determination |
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