Prognostic Value of Epithelial Growth Factor Receptor,Vascular Endothelial Growth Factor,E-Cadherin,and p120 Catenin in Resected Non-Small Cell Lung Carcinoma |
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| Authors: | Ahmet Ucvet Cemil Kul Soner Gursoy Ahmet Emin Erbaycu Seyda Ors Kaya Zekiye Aydogdu Dinc Nur Yucel |
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| Affiliation: | 1. Department of Thoracic Surgery, Dr Suat Seren Chest Diseases and Thoracic Surgery Training Hospital, Izmir, Turkey;2. Department of Pulmonary Diseases, Dr Suat Seren Chest Diseases and Thoracic Surgery Training Hospital, Izmir, Turkey;3. Department of Pathology, Dr Suat Seren Chest Diseases and Thoracic Surgery Training Hospital, Izmir, Turkey;1. University of Massachusetts Lowell, Lowell, MA, USA;2. University of Massachusetts Boston, Boston, MA, USA;3. Wentworth Institute of Technology, Boston, MA, USA;4. Space Coast Cancer Center, Titusville, FL, USA;5. Brigham and Women’s Hospital, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA;1. Posgrado en Biomedicina Molecular, ENMyH, Instituto Politécnico Nacional, México City 07320, Mexico;2. Doctorado en Ciencias en Biotecnología, ENMyH, Instituto Politécnico Nacional, México City 07320, Mexico;3. Laboratorio Multidisciplinario de Investigación, Escuela Militar de Graduados de Sanidad, Universidad del Ejército y Fuerza Aérea, México City 11620, Mexico;1. Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, United States;2. Toxicologic Pathology Associates, National Center for Toxicological Research, Jefferson, AR 72079, United States;3. Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, Jefferson, AR 72079, United States;4. Centro de Química Estrutural, Instituto Superior Técnico, Universidade de Lisboa, 1049-001 Lisboa, Portugal;3. From the Division of Molecular and Cellular Biology, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Hyogo 650-0017, Japan,;4. the Division of Pathogenetic Signaling, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Hyogo 650-0047, Japan,;5. the KAN Research Institute, Inc., Kobe, Hyogo 650-0047, Japan, and;6. the Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency (JST), Kobe, Hyogo 650-0047, Japan;1. Post-Graduate and Research Department of Chemistry, The New College (Autonomous), Chennai 600 014, India;2. Bioengineering and Drug Design Laboratory, Department of Biotechnology, Indian Institute of Technology Madras, Chennai 600 036, India |
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| Abstract: | ![]()
IntroductionSeveral markers have been investigated to predict the prognosis of lung cancer. In the present study, the prognostic values of epithelial growth factor receptor (EGFR), vascular endothelial growth factor (VEGF), E-cadherin, and p120 catenin expression were investigated by immunohistochemistry in patients with a surgically resected non-small cell lung carcinoma (NSCLC).Patients and methodEGFR, VEGF, E-cadherin, and p120 catenin expression were prospectively determined in resected specimens from patients with NSCLC who had undergone surgery between 2003 and 2007. Patients’ and disease-related general characteristics and survival rate were recorded.ResultsOne hundred seventeen patients with a mean age of 61.3 years were included in the study. After a mean follow-up of 27.5 months, the median survival was determined to be 44.0 months and the 5-year survival was 46.2%. The 5-year survival in negative and positive staining groups were as follows; 32% and 66.7% for EGFR (P=.02), 37.8%, and 50.7% for VEGF (P=.5), 41% and 66% for E-cadherin (P=.19), and 46% and 50% for p120 catenin (P=.27). The differentiation, N status, stage, and EGFR staining were variables significantly affecting survival (P=.001, .006, .03, and .02, respectively). In multivariate Cox analysis, the EGFR staining level and N status were variables those significantly affecting survival (P=.021 and P=.010).ConclusionsWhile negative staining of EGFR was related with poor survival, staining of VEGF, E-cadherin, and p120 catenin were not related with survival in patients with resected NSCLC. |
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