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Trastuzumab in combination with metronomic cyclophosphamide and methotrexate in patients with HER-2 positive metastatic breast cancer |
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| Authors: | Laura Orlando Anna Cardillo Raffaella Ghisini Andrea Rocca Alessandra Balduzzi Rosalba Torrisi Giulia Peruzzotti Aron Goldhirsch Elisabetta Pietri Marco Colleoni |
| Affiliation: | (1) Unit of Research in Medical Senology, Department of Medicine, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy;(2) Division of Medical Oncology, Department of Medicine, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy |
| Abstract: | BackgroundHER2/neu overexpression is linked to promotion of angiogenesis in breast cancer. We therefore tested the activity of the combination of Trastuzumab with metronomic, low dose chemotherapy with cyclophosphamide (CTX) and methotrexate (MTX) in metastatic breast cancer (MBC). |
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