| 载脂蛋白E基因启动子多态性与年龄相关性黄斑变性的关系 |
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| 引用本文： | 邵运良,秦艳丽,尹晓光,宋跃,闫亦农. 载脂蛋白E基因启动子多态性与年龄相关性黄斑变性的关系[J]. 汕头大学医学院学报, 2007, 20(1): 28-29 |
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| 作者姓名： | 邵运良 秦艳丽 尹晓光 宋跃 闫亦农 |
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| 作者单位： | 1. 汕头大学香港中文大学联合汕头国际眼科中心,广东,汕头,515041
2. 湛江奥理德眼科医院,广东,湛江,524043 |
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| 摘 要： | 目的:探讨载脂蛋白E(APOE)基因启动子(-219G/T)多态性与年龄相关性黄斑变性(AMD)发病危险性的关系。方法:用聚合酶链反应-限制性片断长度多态性分析法对AMD组(50例)和对照组(95例)的APOE-219G/T基因型做出鉴定。结果:两组间不存在-219G/T基因型频率分布的差异(P>0.39)。结论:APOE基因-219G/T多态性与AMD发病危险性无关。
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| 关 键 词： | 年龄相关性黄斑变性 载脂蛋白E 多态性 |
| 文章编号： | 1007-4716（2007）01-0028-02 |
| 收稿时间： | 2006-11-27 |
| 修稿时间： | 2006-11-27 |
Relationship between the Apolipoprotein E Promoter Polymorphisms and the Risk of Age-related Macular Degeneration |
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| SHAO Yun-liang,QIN Yan-li,YI Xiao-guang,SONG Yue,YAN Yi-nong. Relationship between the Apolipoprotein E Promoter Polymorphisms and the Risk of Age-related Macular Degeneration[J]. Journal of Shantou University Medical College, 2007, 20(1): 28-29 |
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| Authors: | SHAO Yun-liang QIN Yan-li YI Xiao-guang SONG Yue YAN Yi-nong |
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| Affiliation: | 1 STU/CUHK Joint Shantou International Eye Center, Shantou 515041, China; 2 Zhanfiang ALLAD Eye Center, Zhanjiang 524043, China |
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| Abstract: | Objective: To study the relationship between apolipoprotein E(APOE)promoter(-219G/T)polymorphisms and the risk of age-related macular degeneration(AMD).Methods: APOE-219G/T genetype in AMD group(50 cases)and control group(95 persons)was identified by polymerase chain reaction and restriction fragment length polymorphism genotyping technique.Results: No significant difference was found between two groups on the distribution of APOE-219G/T genotype.Conclusion: The APOE-219G/T polymorphisms do not contribute to AMD risk. |
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| Keywords: | age-related macular degeneration apolipoprotein E polymorphism |
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