| 缺血性心脑血管疾病患者血浆因子Ⅶ
水平及临床意义 |
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| 引用本文： | 朱宁,夏纪田,李国成,林智强,俞锐敏,孙蓓.缺血性心脑血管疾病患者血浆因子Ⅶ
水平及临床意义[J].临床心血管病杂志,2001,17(4):168-169. |
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| 作者姓名： | 朱宁 夏纪田 李国成 林智强 俞锐敏 孙蓓 |
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| 作者单位： | 1. 暨南大学医学院第一附属医院急诊科
2. 暨南大学医学院第一附属医院检验科 |
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| 摘 要： | 目的系列测定缺血性心脑血管疾病患者血浆中凝血因子Ⅶ(FⅦ)的水平并探讨其临床意义。方法冠心病60例分为两组①血清胆固醇(TC)与甘油三酯(TG)正常组30例；②血清TC与TG增高组30例。缺血性脑卒中40例，分别采用重组可溶性组织因子法测定活化因子Ⅶ(FⅦ
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| 关 键 词： | 凝血因子Ⅶ 冠状动脉疾病 脑缺血 |
| 文章编号： | 1001－1439(2001)04－0168-02 |
| 修稿时间： | 2000年12月25 |
The serial measurements of
coagulate factor |
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| ZHU Ning,XIA Jitian,Li Guocheng,Lin Zhiqiang,YU Ruimin,Sun Bei.The serial measurements of
coagulate factor[J].Journal of Clinical Cardiology,2001,17(4):168-169. |
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| Authors: | ZHU Ning XIA Jitian Li Guocheng Lin Zhiqiang YU Ruimin Sun Bei |
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| Institution: | ZHU Ning 1 SUN Bei 2 XIA Jitian 1 LI Guocheng 1 LIN Zhiqiang 1 YU Ruimin 1 |
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| Abstract: | Objective:To measure the coagulate factor FⅦ in series and detect its clinical significance in patients with ischemic cerebral and heart disease. Method:Patients with coronary heart disease (n = 60) were divided into 2 groups according to the serum level of cholesteral and triglycerin:Group I ( n =30) with normal values and Group Ⅱ ( n = 30) with increased chlolesterol and triglycerin. Patients with ischemic cerebral stroke (n =40) also had a higher level of cholesteral and triglycerin. FⅦa was detected by recombinant factor method. F ⅦAg and FⅦc were detected by ELISA and phase I coagulation method, respectively, and the ratios of FⅦa/F ⅦAg and FⅦc/FⅦAg were also made out. Result:In group Ⅱ , FⅧa and FⅦc increased by 16% and 14% when the value of cholesteral and triglycerin increased by 66% and 108%, respectively (P ＜0. 05). In patients with ischemic stroke, the value of FⅦa was (2.7±0. 9)μg/L, and FⅦc was (97±26)%, and ratio of FⅦa/FⅦc was higher than that of control ( P ＜0. 05). Conclusion:FⅦ is a risk factor for ischemic cerebral and heart diseases and serial measurement of FⅦ is a more effective method. |
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