甘精胰岛素联合阿卡波糖控制波动性高血糖的疗效观察

目的 观察甘精胰岛素联合阿卡波糖对老年2型糖尿病患者血糖波动的疗效及安全性.方法 根据动态血糖监测系统(CGMS)结果,选择波动性高血糖患者30例,在控制饮食的基础上给予甘精胰岛素联合阿卡波糖治疗3个月,观察治疗前后患者的血糖波动变化.结果 患者糖化血红蛋白(HbA1(c))、平均血糖水平(MBG)、平均血糖水平标准差(SDBG)、平均血糖波动幅度(MAGE)、日间血糖平均绝对差(MODD)分别由治疗前的8.29％±0.73％和(10.06±2.48)、(2.36±0.53)、(5.64±1.22)和(1.72±0.60)mmol/L下降至治疗后的7.37％±0.47％和(8.04±2.25)、( 1.52±0.35)、(4.40±1.02)、( 1.26±0.49)mmol/L,差异均有统计学意义(P＜0.05,P＜0.01).结论 甘精胰岛素联合阿卡波糖可有效控制2型糖尿病患者血糖水平及波动幅度,且安全性高.

The Efficacy of Insulin Glargine Combined with Acarbose in Patients with Fluctuating High Blood Glucose

Objective To study on the efficacy and safety of insulin glargine combined with acarbose in elderly patients newly diagnosed type 2 diabetic mellitus with fluctuating high blood glucose. Methods 30 of patients with fluctuating high blood glucose were selected and given insulin glargine combined with acarbose besides diet control for three months, and their fluctuation of blood glucose was observed at the beginning and the end of the study. Results HbA1C, MBG, SDBG, MAGE and MODD were significantly lower at the beginning than at the end[7.37%±0.47% vs 8.29%±0.73%, （8.04±2.25） vs （10.06±2.48） mmol/L, （1.52±0.35） vs （ 2.36±0.53） mmol/L, （4.40±1.02） vs （5.64±1.22） mmol/L, （1.26±0.49） vs （1.72±0.60） mmol/L, respectively; P〈0.05 or P〈0.01]. Conclusion It might be more effective and safer for elderly patients with type 2 diabetic mellitus to use insulin glargine combined with acarbose in controlling level and fluctuation of blood sugar.