| 血管内皮细胞分泌的炎性递质在急性肺损伤发病机制中的作用 |
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| 引用本文： | 胡宗风,孙海晨. 血管内皮细胞分泌的炎性递质在急性肺损伤发病机制中的作用[J]. 创伤外科杂志, 2009, 11(3): 281-283 |
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| 作者姓名： | 胡宗风 孙海晨 |
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| 作者单位： | 南京大学医学院临床学院,南京军区南京总医院急救医学科,江苏,南京,210002;南京大学医学院临床学院,南京军区南京总医院急救医学科,江苏,南京,210002 |
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| 摘 要： | 肺血管内皮细胞损伤在急性肺损伤（ALI）／急性呼吸窘迫综合征（ARDS）的病理过程中起重要作用，各种血管源性炎症递质可导致血管内皮细胞损伤，提高肺泡-毛细血管通透性，肺血管间质和肺泡腔水肿，发生顽固性低氧血症、呼吸窘迫等临床表现。本文探讨了ALI时各种炎症递质的表达、对肺血管内皮的作用机制及对ALI的病理生理影响。这些可能成为ALI／ARDS新的治疗靶点和研究的方向。
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| 关 键 词： | 肺损伤 急性呼吸窘迫综合征 肺血管内皮细胞 炎性递质 |
Role of inflammatory mediators derived from pulmonary vascular endothelial cells in acute lung injury |
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| HU Zong-feng,SUN Hai-chen. Role of inflammatory mediators derived from pulmonary vascular endothelial cells in acute lung injury[J]. Journal of Traumatic Surgery, 2009, 11(3): 281-283 |
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| Authors: | HU Zong-feng SUN Hai-chen |
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| Affiliation: | Department of Emergency Medicine;Nanjing General Hospital of Nanjing Military Command;Nanjing 210002;China |
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| Abstract: | Pulmonary vascular endothelial cells play a critical role in the pathogenesis of acute lung injury/ acute respiratory distress syndrome.All kinds of mediators derived from vascular endothelial cells increase extra-alveolar endothelial permeability,develop pulmonary edema,lead to hypoxemia and respiratory distress.This article is to explore the expression of endothelia-derived mediators,their affects on pulmonary vascular endothelia cell and the pathophysiology of acute lung injury.These probably will be the... |
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| Keywords: | lung injury acute respiratory distress syndrome pulmonary vascular endothelial cell inflammatory mediators |
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