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| 肺移植闭塞性细支气管炎免疫机制研究进展 | |
| 引用本文： | 王光锁,王正,孙宗全. 肺移植闭塞性细支气管炎免疫机制研究进展[J]. 国际外科学杂志, 2008, 35(5) |
| 作者姓名： | 王光锁 王正 孙宗全 |
| 作者单位： | 深圳市人民医院胸外科,暨南大学第二临床医学院,深圳,518020;华中科技大学同济医学院附属协和医院心血管外科,武汉,430022 |
| 摘 要： | 闭塞性细支气管炎是影响肺移植患者长期生存的主要因素.适应性免疫一直是肺移植排斥反应的研究重点.但是越来越多的研究表明,体液免疫、自体免疫、固有免疫等亦是闭塞性细支气管炎发生的重要因素. |
| 关 键 词： | 肺移植 闭塞性细支气管炎 慢性排斥反应 免疫机制 |
Immune mechanisms of obliterative bronchiolitis following lung transplantation |
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| WANG Guang-Suo,WANG Zheng,SUN Zong-Quan. Immune mechanisms of obliterative bronchiolitis following lung transplantation[J]. International Journal of Surgery, 2008, 35(5) | |
| Authors: | WANG Guang-Suo WANG Zheng SUN Zong-Quan |
| Abstract: | Chronic rejection remains the leading cause of chronic allograft dysfunction and late mortality after lung transplantation. Adaptive immune system and its cellular-based rejection has been the focus in the development of obliterative bronchiolitis. Recent research has identified that humoral immunity, autoimmunity, and innate immunity also contribute to obliterative bronchiolitis. This paper presents an updated review of the immune mechanisms for obliterative bronchiolitis following lung transplantation. |
| Keywords: | lung transplantation obliterative bronchiolitis chronic rejection immune mechanisms |
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