|
|||||
|
|
| 维生素D_3与心肌细胞电活动关系的实验研究 | |
| 引用本文： | 李哲泓,刘红,车承红,杨高扬. 维生素D_3与心肌细胞电活动关系的实验研究[J]. 哈尔滨医科大学学报, 1988, 0(3) |
| 作者姓名： | 李哲泓 刘红 车承红 杨高扬 |
| 作者单位： | 哈尔滨医科大学克山病研究所(李哲泓，刘红，车承红)，哈尔滨医科大学克山病研究所(杨高扬) |
| 摘 要： | 本实验利用标准玻璃微电极技术和微机系统的实时应用,在离体豚鼠右心室乳头肌上观察维生素D_3对其细胞电活动的影响。结果表明维生素D_3可使心肌细胞动作电位和零相最大去极化速率发生明显改变,其变化主要是由于通过细胞膜慢通道有大量的Ca~(2+)内流,使细胞内Ca~(2+)超负荷来实现的。 |
| 关 键 词： | 维生素D_3 动作电位 Ca~(2+)超负荷 |
Experiment Study of the Relationship between Vitamin D_3 and Electrical Activities of Myocardiac Cell |
|
| Li Zhehong et al. Experiment Study of the Relationship between Vitamin D_3 and Electrical Activities of Myocardiac Cell[J]. Journal of Harbin Medical University, 1988, 0(3) | |
| Authors: | Li Zhehong et al |
| Affiliation: | Li Zhehong et al |
| Abstract: | The effects of the vitamin D_3 on electrical activities in papillary muscle cells of guinea pigs were observed and recorded by means of the standard glass microelectrode technique and microcomputer system. The results showed that the APA, OS and RP were all decreased, maximum upstroke velocity of phase O depolarization was also decreased, the APD was shortened, especially APD_(50) was shortened most obviously. It is suggested that Ca~(2+) inward current was increased, so intracellular Ca~(2+) overload happened when vitamin D_3 was used, thus cardiac muscle damage being induced. |
| Keywords: | Vitamin D_3 Action potential Ca~(2+) overload |
| 本文献已被 CNKI 等数据库收录！ | |