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Bone marrow-derived progenitors are greatly reduced in patients with severe COPD and low-BMI |
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| Authors: | Alice Huertas Ugo Testa Roberta Riccioni Eleonora Petrucci Viviana Riti Daniela Savi Pietro Serra Maria Rosaria Bonsignore Paolo Palange |
| Affiliation: | 1. Department of Clinical Medicine, “La Sapienza” University, Viale Università 37, 00185 Rome, Italy;2. Laboratory of Oncology Hematology, ISS, Rome, Italy;3. Department of Medicine, Pneumology, Physiology and Nutrition (DIMPEFINU), University of Palermo, Italy;4. Institute of Biomedicine and Molecular Immunology, National Research Council (CNR), Palermo, Italy |
| Abstract: | Chronic obstructive pulmonary disease (COPD) patients have reduced circulating hemopoietic progenitors. We hypothesized that severity of COPD parallels the decrease in progenitors and that the reduction in body mass index (BMI) could be associated with more severe bone marrow dysfunction. |
| Keywords: | Chronic obstructive pulmonary disease Low-BMI COPD Normal-BMI COPD Fat-free mass |
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