TSGF、CEA、LDH检测在良恶性胸腔积液鉴别诊断中的应用

目的探讨肿瘤特异性生长因子（TSGF）、癌胚抗原（CEA）及乳酸脱氢酶（LDH）三项指标检测在良、恶性胸腔积液鉴别诊断中的应用。方法选择2012年1月至2013年9月住院的108例胸腔积液患者（恶性胸腔积液63例,良性胸腔积液45例）为研究对象。采用全自动生化分析仪和全自动免疫电化学发光仪分别对108例良、恶性胸腔积液及对应的患者血清进行TSGF、CEA和LDH同步检测。结果胸腔积液、血清TSGF、CEA和LDH水平,恶性组均高于良性组（P均〈0.05）;恶性胸腔积液TSGF、CEA和LDH含量均高于血清（P均〈0.05）;胸腔积液、血清单项检测诊断恶性胸腔积液的敏感度及特异度由高到低均依次为TSGF、CEA和LDH。结论胸腔积液、血清TSGF、CEA、LDH检测对鉴别良、恶性胸腔积液有重要临床价值,TSGF的特异度和敏感度均优于CEA和LDH。

Application of TSGF,CEA and LDH in differential diagnosis of benign and malignant pleural effusion

Objective To discuss the applied value of tumor specific growth factor （TSGF） ,carcinoembry- onic antigen （CEA） and lactate dehydrogenase （LDH） in the differential diagnosis of benign and malignant pleural effusion. Methods A total of 108 patients with pleural effusion （ including 63 cases of malignant pleural effusion and 45 cases of benign pleural effusion） admitted between January 2012 and September 2013 were enrolled in this study. The TSGF, CEA and LDH levels in pleural effusion and corresponding serum were synchronously detected u- sing automatic biochemical analyzer and autoimmune electrochemical luminescence analyzer. Results The TSGF, CEA and LDH levels of serum and pleural effusion in malignant pleural effusion patients were all higher than those in benign pleural effusion patients （ all P 〈 0.05 ）. The levels of TSGF, CEA and LDH of pleural effusion in patients with malignant pleural were all higher than those in serum （ all P 〈 O. 05 ）. For the diagnosis of malignant pleural ef- fusion, the sensitivity and specificity of pleural effusion or serum single testing were all TSGF, CEA and LDH from high to low in turn. Conclusions Detecting TSGF, CEA, LDH in serum and pleural effusion has important clinical value in distinguishing benign and malignant pleural effusion. The specificity and sensitivity of TSGF are all superiorto CEA and LDH.