普通高中生不同学年血清儿茶酚胺、皮质醇及白细胞介素2、白细胞介素6水平的变化

目的 探讨普通高中生不同学年血清儿茶酚胺、皮质醇及白细胞介素2、白细胞介素6水平的变化.方法 用放射免疫法和磁性分离酶联免疫法对328名普通高中学生不同学年的血样中的分泌代谢指标肾上腺素(N)、去甲肾上腺素(NE)、皮质醇(CS)及免疫功能指标白细胞介素2(IL-2)、白细胞介素6(IL-6)含量进行测定,并与同时期职业高中生作对照组.结果 普通高中学生随着高考时间临近,N、NE及CS值呈明显上升趋势,IL-2、IL-6则持续下降;高三时[N(268.5±1 19.5)pmol·L-1,NE(1967.5±621.4)pmol·L-1,CS(471.6±121.8)nmol·L-1,IL-2(2.00±1.24)μg·L-1,IL-6(0.193±0.06)μg·L-1]与高二时比较(P<0.01)、高一时比较(P<0.01)及职高对照组比较(P<0.01)各项生理指标均差异有显著性;高二时与高一时比较(t=1.96～2.52,P<0.05)、与职高对照组比较(t=3.53～4.20,P<0,01)各指标差异有显著性,高一时与职高对照组比较各指标差异无显著性(t=1.18～1.92,P>0.05).结论 高三学生血浆N、NE及CS水平较高二时显著增高,而IL-2、IL-6水平显著下降.

Study on the serum catecholamine.cortisol,interleukin-2 and interleukin-6 of the senior high school students during different grade

Objective To observe the student's endocrine metabolism in senior high school during different periods.Methods 328 senior middle school students in different periods were investigated and the blood concentration of adrenaline(N),norepinephrine(NE),cortisol(CS),interleukin-2(IL-2),interleukin-6(IL-6)were measured by radioimmunoassay and Magnetic Solid Phase Separation-Enzyme Immunoassay,and at the same time,students in vocational high school were contrasted.Results As the university entrance examination was coming,the values of N,NE and CS were apparently rising,while the values of IL-2 and IL-6 were going down.The biodifferences.Grade Two and Grade One(t=1.96～2.52,P＜0.05).Grade Two and the control(t=3.53～4.20,P＜0.01)were different significantly,while Grade one and the control had no obvsious difference(t=1.18～1.92,P＞0.05).Conclusion N,NE,CS of the senior hish school students in Grade Three were higher,while IL-2and IL-6 were lower than that of the Grade Two.