CT 灌注成像对胃癌评估的临床应用

目的：探讨 CT 灌注成像参数值与不同分化程度胃癌的相关性。方法应用64层螺旋 CT 对经手术病理证实的50例胃癌患者术前行灌注成像检查,获得灌注参数值,包括血流量(BF)、血容量(BV)、平均通过时间(MTT)和毛细血管表面通透性(PS)；根据肿瘤细胞不同分化程度分成高、中、低分化3组,然后应用 SPSS 17.0软件进行统计分析。结果高分化胃癌组10例(20%),灌注参数：BF 值(mL·min-1·100 g-1)75.28±6.81,BV 值(mL/100 g)9.01±0.94,MTT 值(s)9.89±1.65,PS 值(mL·min-1·100 g-1)10.05±0.71；中分化胃癌组24例(48%),灌注参数：BF 值110.01±31.90,BV 值18.18±5.62,MTT 值9.81±3.69,PS 值40.08±15.82；低分化胃癌组16例(32%),灌注参数：BF 值138.59±38.09,BV 值21.08±4.11,MTT 值9.47±1.80,PS 值57.50±13.28。3组比较,BF、BV、PS 值在高分化与中分化组以及高分化与低分化组间差异有统计学意义(P <0.05),MTT 值在胃癌不同分化3组间差异无统计学意义(P >0.05)。结论CT 灌注参数 BF、BV、PS 值可以作为胃癌恶性程度的评估指标。

Clinical application of CT perfusion imaging in assessment of gastric cancer

Objective To explore the correlation between CT perfusion imaging parameters and differentiation degree of gastric cancer.Methods Fifty patients with gastric cancer proved by surgery and pathology underwent 64-slice spiral CT perfusion imaging before surgery,and the CT perfusion parameters were obtained including blood flow(BF),blood volume(BV),mean transit time (MTT)and permeability surface(PS).The patients were divided into 3 groups (well,moderate and poor differentiation)according to the degree of cell differentiation.Statistical analysis was performed by using the SPSS 17.0 statistics software.Results The perfusion parameters of BF (mL·min-1 ·100 g-1 ),BV (mL/100 g),MTT (s)and PS (mL·min-1 ·100 g-1 )were as follows:75.28±6.81,9.01± 0.94,9.89±1.65 and 10.05±0.71 in well differentiation group with 10 patients (20%),110.01±31.90,18.18±5.62,9.81±3.69 and 40.08±1 5.82 in moderate differentiation group with 24 patients (48%),138.59±38.09,21.08±4.1 1,9.47 ±1.80 and 57.50± 13.28 in poor differentiation group with 1 6 patients (32%)respectively.Among three groups,there were statistic differences in BF, BV and PS between well differentiation group and moderate differentiation group or low differentiation group (P <0.05),however there was no statistic difference in MTT among three groups (P >0.05).Conclusion The BF,BV and PS values may be regarded as the evaluation index for malignant degree of gastric cancer.