3.0TMRI 对青年女性正常子宫ADC 值周期性变化的研究

目的：研究青年女性正常子宫体各结构表观扩散系数（ADC ）值在不同月经周期的变化规律，并探讨其生理机制及临床意义。方法19例健康青年女性分别于围排卵期、分泌晚期及月经期接受3次子宫体扩散加权成像（DWI）（b＝0，1000 s／mm2）扫描，后分别测量子宫内膜、结合带及子宫肌层的ADC值并分析各结构ADC值的差异及其在不同月经周期的变化规律。结果特定月经周期不同子宫结构ADC值之间均有显著统计学差异（P＜0．05），其中子宫肌层ADC值最高，子宫内膜居中，结合带最低；特定子宫结构在不同月经周期下ADC值存在显著统计学差异（F＝55．674，P＜0．05）；月经周期与子宫结构之间存在交互效应（F＝12．501，P＜0．05）。结论不同结构区及月经周期会对子宫ADC值产生影响，采用ADC值分析子宫病变时，应考虑到子宫不同结构区、不同月经周期对子宫ADC值的影响。

A study on the cyclical changes of the apparent diffusion coefficients in the normal uterus of young women with 3 .0T MRI

Objective To investigate the cyclical changes of the apparent diffusion coefficient (ADC) values of the normal uterine zonal structures and explore physiological mechanism and clinical significance of the changes .Methods Nineteen healthy young fe‐male volunteers were selected to receive DWI (b=0 and 1 000 s/mm2 ) scan during periovulatory ,late secretory and menstrual pha‐ses .The ADC values of endometrium ,junctional zone and myometrium were measured and the differences of the ADC values were analyzed .Results The ADC values among three structures were significantly different in three phases (P< 0 .05) .The ADC value of myometrium was highest and the second was endometrium and the last was junctional zone .The differences of specific uterine zonal structures in different phases were statistically significant (F=55 .674 ,P<0 .05) .There was a interaction effect between menstrual cycle and uterine structures .Conclusion The effect of zones and different phases of the menstrual cycle in young women on ADC val‐ues of uterine structures should be considered when use ADC values to diagnose uterine diseases .