| 采用基因表达数据集分析UBE2C与膀胱癌临床病理特征和预后的相关性 |
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| 引用本文： | 翁鸿,曾宪涛,黄桥,高群竣,王行环.采用基因表达数据集分析UBE2C与膀胱癌临床病理特征和预后的相关性[J].现代泌尿外科杂志,2019(1):19-23. |
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| 作者姓名： | 翁鸿 曾宪涛 黄桥 高群竣 王行环 |
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| 作者单位： | 武汉大学中南医院泌尿外科;武汉大学中南医院循证与转化医学中心;武汉大学循证与转化医学中心;深圳市第二人民医院医学重编程技术重点实验室;深圳市第二人民医院泌尿外科 |
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| 基金项目： | 国家重点研发计划专项基金(No.2016YFC0106300) |
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| 摘 要： | 目的分析UBE2C基因表达与膀胱癌患者临床病理特征及预后的相关性。方法采用Oncomine数据库整合分析出肌层浸润性膀胱癌与正常膀胱组织表达差异最显著的基因作为候选目的基因,然后采用GSE13507基因表达数据集来分析该目的基因与膀胱癌临床病理特征和预后的相关性。结果 Oncomine数据库分析得到UBE2C为差异最显著的基因。GSE13507基因表达数据集分析结果显示,UBE2C基因表达水平在男性中高于女性(P=0.005),在肌层浸润性膀胱癌患者中高于非肌层浸润性膀胱癌患者(P=0.001),在T分期(P=0.001)和N分期(P=0.036)更高者高于分期更低者,在肿瘤进展患者中高于无进展患者(P=0.011);但在患者年龄(P=0.264)、远处转移(P=0.711)和肿瘤复发(P=0.481)方面无统计学差异。UBE2C基因诊断膀胱癌的曲线下面积为0.804,生存分析显示UBE2C基因高表达组的预后差于低表达组(HR=1.82,95%CI:1.13～2.94,Logrank P=0.011)。结论 UBE2C基因高表达可能与膀胱癌肌层浸润、高T分期、高N分期和不良预后相关。
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| 关 键 词： | 膀胱癌 UBE2C 诊断 预后 生物信息学 |
Association between UBE2C expression and clinical pathological characteristics as well as prognosis of bladder cancer |
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| WENG Hong,ZENG Xian-tao,HUANG Qiao,GAO Qun-jun,WANG Xing-huan.Association between UBE2C expression and clinical pathological characteristics as well as prognosis of bladder cancer[J].Journal of MOdern Urology,2019(1):19-23. |
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| Authors: | WENG Hong ZENG Xian-tao HUANG Qiao GAO Qun-jun WANG Xing-huan |
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| Institution: | (Department of Urology,Zhongnan Hospital of Wuhan University,Wuhan 430071;Center for Evidence-based and Translational Medicine,Zhongnan Hospital of Wuhan University,Wuhan 430071;Center for Evidence-based and Translational Medicine,Wuhan University,Wuhan 430071;Key Laboratory of Medical Reprogramming Technology,Second People s Hospital of Shenzhen,Shenzhen 518035;Department of Urology,Second People's Hospital of Shenzhen,Shenzhen 518035,China) |
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| Abstract: | WENG Hong;ZENG Xian-tao;HUANG Qiao;GAO Qun-jun;WANG Xing-huan(Department of Urology,Zhongnan Hospital of Wuhan University,Wuhan 430071;Center for Evidence-based and Translational Medicine,Zhongnan Hospital of Wuhan University,Wuhan 430071;Center for Evidence-based and Translational Medicine,Wuhan University,Wuhan 430071;Key Laboratory of Medical Reprogramming Technology,Second People s Hospital of Shenzhen,Shenzhen 518035;Department of Urology,Second People's Hospital of Shenzhen,Shenzhen 518035,China) |
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| Keywords: | bladder cancer UBE2C diagnosis prognosis bioinformatics |
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