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| Raf激酶抑制蛋白对促分裂原活化蛋白激酶通路的调控作用 | |
| 引用本文： | 李煌,吴拓江,李松,陈扬熙. Raf激酶抑制蛋白对促分裂原活化蛋白激酶通路的调控作用[J]. 国际口腔医学杂志, 2008, 35(3) |
| 作者姓名： | 李煌 吴拓江 李松 陈扬熙 |
| 作者单位： | 南京大学医学院附属口腔医院正畸科,江苏,南京,210008;南京医科大学附属口腔医院正畸科,江苏,南京,210029;昆明医学院,云南,昆明,650031;四川大学华西口腔医院正畸科,四川,成都,610041 |
| 摘 要： | Raf激酶抑制蛋白是一种高度保守的表达蛋白,它作为促分裂原活化蛋白激酶信号级联反应的内源性调控者,在生物体的生长和分化中扮演着重要的作用。Raf激酶抑制蛋白位于促分裂原活化蛋白激酶级联反应的交叉口,能调控多条信号传导通路,主要通过调节Raf-1的活性来介导其调控机制。因此,Raf激酶抑制蛋白可能是促分裂原活化蛋白激酶级联通路中一个新的关键调控位点。 |
| 关 键 词： | 促分裂原活化蛋白激酶 Raf激酶抑制蛋白 Raf 蛋白激酶C |
Regulation role of Raf kinase inhibitory protein to mitogen-activated protein kinase signaling pathway |
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| LI huang,WU Tuo-jiang,LI Song,CHEN Yang-xi. Regulation role of Raf kinase inhibitory protein to mitogen-activated protein kinase signaling pathway[J]. Journal of International Stomatology, 2008, 35(3) | |
| Authors: | LI huang WU Tuo-jiang LI Song CHEN Yang-xi |
| Abstract: | Raf kinase inhibitory protein(RKIP) that serve as endogenous modulators of mitogen-activated protein kinase(MAPK) signaling pathway, have been demonstrated to play an increasingly important role in growth and differentiation in organisms. RKIP is a highly conserved, ubiquitously expressed protein. RKIP is identified as playing a role in MAPK cascade, and identification of the mechanism by which it regulates Raf-1 activation. |
| Keywords: | mitogen-activated protein kinase Raf kinase inhibitory protein Raf protein kinase C |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |