抗类风湿关节炎中药经皮给药制剂研究进展

类风湿关节炎(RA)是一种慢性、全身性自身免疫性疾病,发病率高、致残率大,是威胁人类健康和生活的重大疾病之一。目前尚无特效药物,临床上多以非甾体抗炎药、抗类风湿性药及糖皮质激素类药用于RA的治疗,但用药过程中多伴有强烈不良反应,患者顺应性较差。中药具有多成分、多靶点作用,在此基础上开发出的中药经皮给药制剂具有给药次数少、患者依从性高、可有效避免食物对药物的影响的特点,且使用方便安全、可随时中断用药。中药经皮给药制剂因其独特的治疗效果及剂型优势已成为研究的热点。本文以治疗RA的中药经皮给药制剂为出发点,评述与探讨其研究的必要性、研究现状及存在问题,提出应着重加强物质基础研究、应保证良好的制剂质量控制、应加强外用辅料研究和传统中药外用制剂机制的研究、加强中药促渗剂科学使用研究等建议,为RA中药经皮给药系统的研究与开发提供参考。

Research Progress in Transdermal Drug Delivery System of Traditional Chinese Medicine on Rheumatoid Arthritis

Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease with a high incidence and disability rate.Currently,RA is deemed as one of major diseases threatening human health and life,but with no effective drug.In clinic,common drugs for RA included nonsteroidal anti-inlammatory drugs,disease modifying antirheumatic drugs and corticosteroids clinically.However,they have severe adverse reactions,which bring great pains to patients.Traditional Chinese medicine (TCM) feature multiple components and multiple-target effect,based on which TCM transdermal drug delivery preparations have advantages of low medicinal frequency,high compliance among patients,effective reduction of foods' impacts on drugs,convenience,safety and drug withdrawal at anytime.Transdermal drug delivery preparations have become a hotspot of studies because of their unique therapeutic effect and formulation superiority.In this dissertation,authors evaluated and discussed necessity,current situation and existing problems of TCM transdermal drug delivery preparations,and gave their own suggestions,such as strengthen the material base studies,ensure a good quality control of preparation,strengthen studies on the external excipients and the mechanism of external TCM preparations,strengthen the studies on the scientific use of TCM penetration enhancer,in expectation of providing a reference for research and development of TCM transdermal drug delivery system.