抑郁症伴功能性消化不良患者血清BDNF、MTL与SS水平的测定

目的 探讨抑郁症伴功能性消化不良患者血清中脑源性神经营养因子（BDNF）、胃动素（MTL）和生长抑素（SS）的水平及意义.方法 对50例抑郁症伴功能性消化不良患者进行临床评价,用氟西汀（晨服20mg,1次/日）联合多潘立酮（10mg/次,3次/日,饭前30分钟口服）治疗8周,另设健康组.采用放免法测定健康组与患者组治疗前后血清中BDNF、MTL和SS的水平.结果 （1）健康组BDNF、MTL和SS水平分别为（18.03±5.1）ng/ml、（228.40±38.9）pg/ml和（458.3±37.6）pg/ml,患者组血清中BDNF、MTL和SS水平分别为（12.8±3.7）ng/ml、（107.8±20.2）pg/ml、（682.1±59.6）pg/ml,与健康组比较,患者血清中BDNF和MTL的水平明显降低,SS水平明显升高,差异有显著性（均P〈0.01） （2）治疗后患者组血清中BDNF、MTL和SS水平分别为（19.2±5.6）ng/ml、（223.9±44.2）pg/ml、（474.1±50.3）pg/ml,BDNF和MTL水平较前明显增高,SS水平明显降低,与治疗前比较差异有显著性（均P〈0.01）,与健康对照组比较均为P〉0.05.结论 抑郁症伴功能性消化不良患者血清BDNF、MTL降低,SS水平升高,治疗后血清中BDNF、MTL水平增高,SS水平较前明显下降,均向健康水平回归,提示BDNF、MTL和SS在抑郁症伴功能性消化不良的发病过程中可能起重要作用.

Detection of BDNF、MTL and SS in Serum of Depression with Functional Dyspepsia Patients

Objective To investigate the serum level of BDNF（Brain-derived neurotrophic factor）, MTL（Motilin） and SS（Somatostatin） in depression with FD（Functional dyspepsia） and their roles in the pathogenesis of depression with FD. Methods 50 cases depression with FD patients were collected and clinical evaluation was conducted. All patients were treated with Fluoxetine（20mg, 1time/day） combined with Domperidone（10mg/time, 3times/day） for 8 weeks. RIA was used to study the serum level of BDNF, MTL and SS of 20 healthy controls and 50 patients before and after treatment. Results （1）The serum levels ofBDNF, MTLand SSof healthy controls were （18.03±5.1）ng/ml, （228.40±38.9）pg/ml, （458.3±37.6）pg/ml respectively, the levels of the patients of depression with FD were （12.8±3.7）ng/ ml, （107.8±20. 2）pg/ml, （682.1±59.6）pg/ml respectively, the serum levels of BDNF and MTL of patients were significantly lower and SS significantly higher than that of the healthy controls（all P〈0. 01）. （2）After treatment the serum levels of BDNF, MTL and SS were （19.2±5.6）ng/ml, （223.9±44. 2）pg/ ml and （474. 1±50.3）pg/ml respectively, significantly changed comparing with that of before treatment, all P〈0.01 ; Comparing with that of the healthy group, all P〉0.05. Conclusion There is a down-regulation of BDNF, MTL and up-regulation of SS serum level for depression with FD. After treatment with Fluoxetine and Domperidone the serum levels of BDNF, MTL and SS significantly changed comparing with that of before treatment. The results indicate that BDNF, MTL and SS may play an important role in the pathogenesis of depression with FD.