| 反相高效液相色谱法测定盐酸托烷司琼的人体血药浓度 |
| |
| 引用本文： | 付良青,黄丰,唐欣,钱平利,刘泽原.反相高效液相色谱法测定盐酸托烷司琼的人体血药浓度[J].中国药理学通报,2004,20(4):474-476. |
| |
| 作者姓名： | 付良青 黄丰 唐欣 钱平利 刘泽原 |
| |
| 作者单位： | 1. 军事医学科学院附属医院临床药理室,北京,100850
2. 暨南大学药学院中药教研室,广州,510632 |
| |
| 摘 要： | 目的 建立测定盐酸托烷司琼的人体血药浓度的方法 ,用于其血药浓度测定并进行临床药代动力学研究。方法 采用高效液相 -二极管阵列色谱法测定盐酸托烷司琼的血药浓度。结果 盐酸托烷司琼的校正标准曲线方程为 ^Y= - 0 0 35 7+0 0 1 7X(r=0 990 9) ,其 5 ,1 0 ,2 5 μg·L-1 3浓度的血样回收率分别为 1 0 3 2 4 % ,97 5 1 % ,1 0 4 95 % ;精密度分别 5 6 7% ,7 83% ,8 1 8% ;志愿受试者禁食口服 2 0mg盐酸托烷司琼胶囊后 ,盐酸托烷司琼的Cmax为 2 7 4 4 μg·L-1 。结论 此方法可满足测定要求 ,可用于盐酸托烷司琼的药代动力学研究
|
| 关 键 词： | 盐酸托烷司琼 血药浓度 高效液相色谱 |
| 文章编号： | 1001-1978(2004)04-0474-03 |
| 修稿时间： | 2003年8月22日 |
Determination of plasma concentration of tropisetron chlorate by HPLC |
| |
| FU Liang Qing,HUANG Feng,TANG Xin,QIAN Ping Li,LIU Ze Yuan.Determination of plasma concentration of tropisetron chlorate by HPLC[J].Chinese Pharmacological Bulletin,2004,20(4):474-476. |
| |
| Authors: | FU Liang Qing HUANG Feng TANG Xin QIAN Ping Li LIU Ze Yuan |
| |
| Abstract: | S AIM To develop a method which can determine the blood concentration of tropisetron chlorate in order to study its clinical pharmacokinetics. METHODS The blood concentration of tropisetron chlorate was determinated by HPLC. RESULTS Calibrated standard curve of tropisetron chlorate in blood is =-0 035 7+0 017 X ( r =0 990 9), the recoveries of three concentrations 5, 10, 25 μg·L -1 are 103 24%, 97 51%, 104 95%, respectively; and the precisions are 5 67%, 7 8%,8 18%, respectively. After 20 mg tropisetron chlorate were administered by a voluteer via oral, C max of tropisetron chlorate was 27 44 μg·L -1 . CONCLUSION The method is good enough to study pharmacokinetics of tropisetron chlorate. |
| |
| Keywords: | tropisetron plasma concentration HPLC |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
