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| 奥沙拉嗪合成工艺的改进 | |
| 引用本文： | 陈小全,翟虎,周秀艳,邵辉莹,毕玉水,左之利,李保庆.奥沙拉嗪合成工艺的改进[J].中国药房,2008,19(16):1222-1223. |
| 作者姓名： | 陈小全 翟虎 周秀艳 邵辉莹 毕玉水 左之利 李保庆 |
| 作者单位： | 1. 泰山医学院化学与化学工程学院,泰安市,271000 2. 四川大学化工学院,成都市,610065 3. 中国科学院上海药物研究所,上海市,201203 |
| 摘 要： | 目的:探讨合成奥沙拉嗪的新方法。方法:以水杨酸为原料,以文献报道方法为基础,在超声波作用下合成药物奥沙拉嗪。结果:通过与文献报道路线的对比,可知在超声波作用下合成此药物反应时间由原先的8·0h缩短到4·5h、产率由26·3%提高到31·2%。结论:此法适用于合成药物奥沙拉嗪。 |
| 关 键 词： | 合成 奥沙拉嗪 水杨酸 改进 |
Improvement of Synthesizing Technological of Olsalazine |
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| CHEN Xiao-quan,ZHAI Hu,ZHOU Xiu-yan,SHAO Hui-ying,BI Yu-shui,ZUO Zhi-li,LI Bao-qing.Improvement of Synthesizing Technological of Olsalazine[J].China Pharmacy,2008,19(16):1222-1223. | |
| Authors: | CHEN Xiao-quan ZHAI Hu ZHOU Xiu-yan SHAO Hui-ying BI Yu-shui ZUO Zhi-li LI Bao-qing |
| Institution: | CHEN Xiao-quan, ZHAI Hu, SHAO Hui-ying, BI Yu-shui, LI Bao-qing,ZHOU Xiu-yan,ZUO Zhi-li(Chemistry and Chemical Engineering School, Taishan Medical University, Taian 271000, China;Chemical Engineering School, Sichuan University, Chengdu 610065, China;Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China) |
| Abstract: | OBJECTIVE： To explore a new technology for synthesizing of olsalazine. METHODS： Olsalazine was synthesized refered to the methods reported from literature with salicylic acid as raw material under the action of ultrasound. RESULTS： As compare with the route reported in literature, by this new method, the drug reaction time was shortened from 8.0 hours to 4.5 hours while the yield increased from 26.3% to 31.2%. CONCLUSION： This new technology can be applied to synthesize olsalazine. |
| Keywords: | Synthesis Olsalazine Salicylic acid Improvement |
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