细胞毒性T淋巴细胞在乙型肝炎中的作用研究

乙型肝炎病毒(HBV)感染后,决定病情严重程度及病程转归的一个主要因素是机体的免疫反应能力。由于患者体内抗病毒特异性细胞毒性T淋巴细胞(CTL)在清除病毒方面发挥重要功能,CTL通过非细胞裂解机制控制HBV感染,本文就CTL在乙型肝炎中作用,针对HBV的主要组织相容性复合体Ⅰ类分子的CTL反应特异性,CTL的细胞效应机制以及慢性乙型肝炎患者HBV特异性CTL反应低下的原因等几方面的研究近况进行了综述。

Effective Study of Cytotoxic T Lymphocyte in Type B Hepatitis

Once infected by HBV(hepatitis B virus),immunoreac tion ability of t he body is the key factor determining severity of pathogenetic condition and turnover of course of disease.Because of its important role in cleaning virus,CTL can control the infection of HBV by mechanism of non-cell dis ruption.This article reviews CTL about its effect on type B hepatitis,its re active specificity of major histocompatibility complex(MHC)aiming at HBV,me chanism of cytological effect,reasons for low CTL responsive specificity in HB V of the patient with chronic HBV and so on.