胱抑素C在2型糖尿病患者早期肾病中的诊断价值

目的 探讨胱抑素C(Cys-C)在2型糖尿病患者早期肾病中的诊断价值.方法 纳入2016年6月至2017年12月我院内分泌科门诊收治及住院的2型糖尿病患者167例,根据美国肾脏病基金会的标准将患者分为A组[85例,估算肾小球滤过率(eGFR)≥90 mL/(min·1.73 m2)]和B组[82例,eGFR 60～89...

Diagnostic value of cystatin C in early nephropathy of type 2 diabetes patients

Objective To explore the diagnostic value of cystatin C(Cys-C)in early nephropathy of type 2 diabetes patients.Methods A total of 167 patients with type 2 diabetes admitted and hospitalized in the endocrinology department of our hospital from June 2016 to December 2017 were included.According to the criteria of American kidney foundation,the patients were divided into group A[85 cases,estimated glomerular filtration rate(eGFR)≥90 mL/(min·1.73 m~2)]and group B[82 cases,eGFR 60-89 mL/(min·1.73 m~2)].Another 50 normal people who underwent physical examination were included as normal control group(NC group).The height and weight of all subjects were measured,and the body mass index(BMI)was calculated.The total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),fasting blood glucose(FBG),glycosylated hemoglobin(HbA1c),serum creatinine(Scr),urea nitrogen(Urea),uric acid(UA),Cys-C,24 h urinary albumin level were measured.The clinical indexes and renal function indexes of the three groups were compared,and the correlation between eGFR and Cys-C,24 h urinary albumin,Urea,UA were analyzed.Results The levels of Scr,Urea and Cys-C of the group A and the group B were significantly higher than those of the NC group,and those in the group B were significantly higher than the group A(P<0.05).There were no significant differences in UA and 24 h urinary albumin levels between the group A and the NC group(P>0.05);UA and24 h urinary albumin levels of the group B were significantly higher than those of the NC group and the group A(P<0.05).Pearson linear correlation analysis results showed that eGFR were negatively correlated with Cys-C and Urea(r=-0.419,-0.435,P<0.001),and eGFR had no significant correlation with 24 h urinary albumin and UA(r=0.074,-0.082,P=0.288,0.347).Conclusion Cys-C can detect the early renal function damage of diabetic patients earlier than 24 h urinary albumin,which plays an important screening role in the early diagnosis of diabetic nephropathy.