间充质干细胞治疗椎间盘退行性疾病:基于Web of Science数据库的文献计量及可视化分析

背景:间充质干细胞具有自我更新和多向分化的特性,在治疗椎间盘疾病中具有巨大的潜力和应用前景.目的:针对间充质干细胞治疗椎间盘退行性疾病相关文献进行文献计量学分析,了解该领域的研究热点、发展趋势,为其后续发展提供依据和建议.方法:以间充质干细胞治疗椎间盘退行性疾病为主题,检索2000至2019年Web of Scienc...

Mesenchymal stem cells for treatment of intervertebral disc degeneration:a bibliometric and visualization analysis based on Web of Science database

BACKGROUND: Mesenchymal stem cells have the characteristics of self-renewal and multi-directional differentiation, and have great potential and applicationprospects in the treatment of intervertebral disc diseases.OBJECTIVE: To analyze the literature of mesenchymal stem cells in the treatment of intervertebral disc degenerative diseases using bibliometric analysis, and tounderstand the research trends and hotspots in this field, and to provide basis and suggestions for its follow-up development.METHODS: With the theme of mesenchymal stem cell therapy for intervertebral disc degeneration, we searched the relevant literature included in the Webof Science database from 2000 to 2019, analyzed the annual number of paper published, and scientific research funding. Citespace5.5.R2 software was usedto analyze the cooperation relationship of authors, countries and research institutions, the co-citation of journals or literatures. Finally, cluster analysis, burstanalysis and time zone graph analysis were performed on keywords.RESULTS AND CONCLUSION: (1) A total of 648 papers were included, with journal articles as the main type of literature. (2) Most of the funding weresponsored by China and USA (more than 50%). (3) A total of 206 authors were included, out of whom 70 authors published more than 3 papers, and theprincipal researchers were Daisuke Sakai (Japan) focusing on mesenchymal stem cells transplantation for intervertebral disc degeneration, Judith A Hoyland(Great Britain) focusing on regulation of myeloid cell phenotype by mesenchymal stem cells, and Makarand V Risbud (US) focusing on induction of mesenchymalstem cell differentiation. (4) 125 countries and institutions were included: China and USA were the two main countries. (5) 154 journals were included, as SPINEwas the journal with the most published articles. (6) The keyword analysis showed that the research in this field can be divided into three phases: phase 1 from2005 to 2012, mainly investigating gene expression differences, chondrogenic differentiation of mesenchymal stem cells, and extracellular matrix changes inthe intervertebral disc;phase 2 from 2012 to 2017, mainly investigating mesenchymal stem cell injection therapy and changes in the microenvironment of theintervertebral disc;phase 3 from 2017 to 2019, the main study is cell therapy and disc regeneration promoted by mesenchymal stem cells. (7) The probablyresearch direction was to extract mesenchymal stem cells and induce their differentiation to nucleus pulposus, paracrine secretion of mesenchymal stem cellson the function of disc cells and mesenchymal stem cells combined with tissue engineering technology to promote intervertebral disc regeneration.