低强度脉冲超声治疗骨折的系统回顾和荟萃分析

目的:虽然许多随机试验表明低强度脉冲超声可促进骨折愈合,但因研究样本量小、统计学者主观差异等重要评价结果不一致.系统评价低强度脉冲超声治疗骨折的疗效.方法:利用PubMed、Cochrane、Library、Embase、中国知网、万方医学网、维普等数据库及人工检索南昌大学图书馆,搜索并收集采用低强度脉冲超声对骨折治疗...

Low-intensity pulsed ultrasound in treatment of fractures:a systematic review and meta-analysis

OBJECTIVE:Although many randomized trials have shown that low-intensity pulsed ultrasound can promote fracture healing,important evaluation results such as small sample size and subjective differences of statisticians are inconsistent.This study aimed to evaluate the efficacy of low-intensity pulsed ultrasound in the treatment of fractures.METHODS:PubMed,Cochrane Library,Embase,CNKI,Wanfang Medical Network,VIP databases,and Nanchang University Library were searched to collect randomized controlled studies on the impact of low-intensity pulsed ultrasound on fracture treatment from March 1999 to March 2020.Two evaluators independently conducted quality evaluation,data extraction and cross-check on the included studies.Finally,RevMan 5.3 software was used to perform metaanalysis on the relevant data.RESULTS:(1)A total of 11 randomized controlled trials were included,including 1515 patients.The 765 patients in the trial group were treated with lowintensity pulsed ultrasound,and the 750 patients in the control group were treated with placebo or only ordinary instrument treatment group.(2)Metaanalysis showed that healing time of fracture was shorter in the trial group than that in the control group[MD=-17.92,95%CI(-28.44,-7.41),P=0.0008].There was no significant difference in incidence of nonunion and delayed union after fracture,time to return to full load,time to return to work,clinical standard fracture healing time,incidence of nonunion and delayed union of upper limb and lower limb,quality of life improvement and pain reduction(P>0.05).CONCLUSION:Low-intensity pulsed ultrasound can shorten the healing time of fracture.