干细胞治疗多发性硬化及视神经脊髓炎谱系疾病的有效性和临床应用限制

背景:干细胞的自我更新及分化潜能使其成为医学领域中的研究热点,其免疫调节、神经保护等作用使干细胞在多发性硬化、视神经脊髓炎谱系疾病中的应用受到临床医生的青睐.目的:总结近几年来干细胞治疗多发性硬化及视神经脊髓炎谱系疾病的研究进展.方法:通过检索PubMed、Web of science数据库中近几年发表的与干细胞治疗多...

Effectiveness and clinical application limitations of stem cells in the treatment of multiple sclerosis and optic neuromyelitis spectrum diseases

BACKGROUND:The self-renewal and differentiation potential of stem cells make it a research hotspot in the medical field.Its immune regulation and neuroprotective effects make stem cells applications in multiple sclerosis and optic neuromyelitis spectrum diseases favored by clinicians.OBJECTIVE:To summarize the research progress of stem cells in multiple sclerosis and optic neuromyelitis spectrum diseases in recent years.METHODS:The PubMed and Web of Science databases were searched for documents related to stem cell therapy for multiple sclerosis and optic neuromyelitis spectrum diseases published in recent years.Search terms are“stem cells,multiple sclerosis,MS,EAE,neuromyelitis optica spectrum diseases,neuromyelitis optica,NMO,NMODS”.According to inclusion and exclusion criteria,75 related articles were included for careful reading and comprehensive analysis.RESULTS AND CONCLUSION:Compared with past immunosuppressive therapies,stem cell transplantation has great potential for the treatment of multiple sclerosis and optic neuromyelitis spectrum diseases.However,cell selection,donor source,transplantation time,route,post-transplantation long-term safety and effectiveness limit clinical applications.