阿帕替尼联合TP方案化疗对非小细胞肺癌患者肿瘤标志物、MMP-9及MMP-2水平的影响

目的 探讨阿帕替尼联合TP方案化疗对非小细胞肺癌患者肿瘤标志物、MMP-9及MMP-2水平的影响.方法 将86例非小细胞肺癌患者根据随机数字表法分为对照组与观察组,各43例.对照组给予TP方案化疗,观察组在对照组基础上给予阿帕替尼.比较两组的临床效果.结果 观察组的治疗总有效率高于对照组(P<0.05).治疗后,两组的...

Effects of apatinib combined with TP regimen chemotherapy on the tumor markers,MMP-9 and MMP-2 levels in patients with non-smallcell lung cancer

Objective To explore the effects of apatinib combined with TP regimen chemotherapy on the tumor markers,MMP-9 and MMP-2 levels in patients with non-small cell lung cancer.Methods A total of 86 patients with non-small cell lung cancer were divided into control group and observation group according to the random number table method,with 43 cases in each group.The control group was given TP regimen chemotherapy,and the observation group was given apatinib on the basis of the control group.The clinical effects of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05).After treatment,the levels of CA125,CEA,CA199,MMP-9,MMP-2 and VEGF in the two groups decreased,and those in the observation group were lower than the control group(P<0.05).Conclusion The apatinib combined with TP regimen chemotherapy in the treatment of non-small cell lung cancer has significant clinical effect,it can reduce the level of serum tumor markers,and down regulate the expression of serum MMP-9 and MMP-2.