发热伴血小板减少综合征死亡病例的流行病学和临床特征分析

目的 探讨发热伴血小板减少综合征（SFTS）死亡病例的流行病学和临床特征.方法 应用病例-对照研究方法,分别对16例SFTS死亡病例（病例组）和16例一般病例（对照组）的临床与流行病学信息进行统计分析,本研究所有病例均为发热伴血小板减少综合征实验室确诊病例.结果 病例组和对照组有蜱叮咬史的比例分别为25.00％和18.75％,有田间劳作史的比例分别为75.00％和81.25％,差异均无统计学意义（P值均＞0.05）.死亡病例发病至死亡平均时间为10天,发病至确诊平均时间为4天.病例组从发病到首诊的时间间隔和住院治疗天数均显著小于对照组,差异有统计学意义（P值均＜0.05）.62.50％的死亡病例伴有基础疾病,显著高于对照组25％的比例,差异有统计学意义（P=0.035）.病例组具有神经系统症状的比例（87.50％）显著高于对照组（37.50％）,差异有统计学意义（P＜0.05）.病例组ALT、AST、LDH、CK和BUN均高于对照组,但两组比较差异均无统计学意义.结论 既往有基础疾病史和有神经系统症状的患者,死亡风险较高.

Analysis on epidemiologic and clinical characteristics of fatal cases of severe fever with thrombocytopenia syndrome

To explore the epidemiologic and clinical characteristics on fatal cases of severe fever with thrombocytopenia syndrome （SFTS）,the information of 16 fatal cases （case group） and 16 non-fatal cases （control group） of SFTS were analyzed statistically using case-control study.Results showed that the proportions of tick bites in case group and control group were 25.00% and 18.75%,and field work history were 75.00 % and 81.25%,respectively.There was no statistical significance for the proportions of tick bites and field work history between two groups.The time interval from onset to death for case group averaged 10 days,and averaged 4 days from onset to diagnosis.There were statistical significances for time interval from onset to seeing doctor and days of hospitalization between two groups.About 62.5% of fatal case-patients had underlying diseases,which was higher than that in control group （25 %） with statistical significance （P=0.035）.The proportions of neurological symptoms in case group were significantly higher than that in control group （P〈0.05）.The ALT,AST,LDH,CK and BUN in case group were higher than those in control group.However,there was no statistical significance.It＇s suggested that patients with underlying diseases and neurological symptoms have higher death risk.