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Inmjnostimjlant Activity of A Novel Lipopeptide and Its Protective Action Against Leishmnia Donovani |
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| Authors: | A. Puri S. Y. Rizvi W. Haq P. Y. Guru B. Kundu R. P. Saxena R. Shukla K. B. Mathur K. C. Saxena |
| Affiliation: | a Division of Biochemistry, Central Drug Research Institute, Lucknow, INDIAb Division of Biopolymers, Central Drug Research Institute, Lucknow, INDIAc Division of Parasitology, Central Drug Research Institute, Lucknow, INDIAd Division of Pharmacology, Central Drug Research Institute, Lucknow, INDIA |
| Abstract: | Novel lipopeptides 84/201 and 86/450 synthesized in this laboratory stimulated antibody and delayed type hypersensitivity (DTH) response to ovalbumin in guinea pigs. Lipopeptide 86/450 also stimulated antibody and DTH responses in albino mice and enhanced nonspecifically macrophage migration index (fvMI), phagocytic activity and incorporation of [14C] glucosamine in peritoneal macrophages of the treated animals. Proliferative response of splenocytes from lipopeptide 86/450 treated animals was significantly higher than that from untreated controls. Peritoneal macrophages from lipopeptide 86/450 treated mice were less susceptible to Leishmania donovani promastigote invasion when co-cultured in vitro. the treated animals on challenge with L. donovani promastigote/amastigote showed 80 to 90% lower intake of infection than the control animals. |
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