| 脑出血患者颅内血肿中血红素加氧酶1和非结合胆红素的含量变化及其与迟发性脑水肿的关系研究 |
| |
| 引用本文： | 李莉,李波,张书琼,薛维. 脑出血患者颅内血肿中血红素加氧酶1和非结合胆红素的含量变化及其与迟发性脑水肿的关系研究[J]. 临床荟萃, 2009, 24(1) |
| |
| 作者姓名： | 李莉 李波 张书琼 薛维 |
| |
| 作者单位： | 1. 重庆三峡中心医院神经内科,重庆,404000
2. 重庆三峡中心医院检验科,重庆,404000 |
| |
| 摘 要： | 目的研究脑出血患者颅内血肿中的血红素加氧酶1(HO-1)和非结合胆红素(UCB)的含量变化,探讨脑出血后迟发性脑水肿的病理机制。方法选择脑出血行颅内血肿微创清除术患者30例(脑出血组),同时选择健康体检者20例(对照组);用酶联免疫吸附测定(ELISA)法和钒酸盐氧化法检测对照组和脑出血组第1天、第3天和第6天颅内血肿中的HO-1和UCB含量,并应用多田公式计算术后第6天血肿周围脑水肿的体积。结果脑出血组第1天颅内血肿中HO-1的含量(13.96±4.83)μg/L和UCB的含量(11.34±2.96)μmol/L均较对照组(3.53±2.07)μg/L、(7.13±2.74)μmol/L明显增高(P<0.01);并且脑出血组第3天HO-1、UCB(25.60±7.13)μg/L、(28.45±7.69)μmol/L均达到高峰,第6天(18.77±5.39)μg/L,(20.18±4.75)μmol/L有所下降,与第1天比较差异均有统计学意义(P<0.01)。并且第6天HO-1和UCB的含量与脑水肿的体积均呈正相关(r值分别为0.453、0.525,均P<0.05)。结论HO-1和UCB可能在脑出血后迟发性脑...
|
| 关 键 词： | 脑出血 外科手术 微创性 血红素加氧酶1 胆红素 |
Contents and clinical significance of heme oxygenase-1 and unconjugated bilirubin in intracranial hematoma of cerebral hemorrhage patients |
| |
| LI Li,LI Bo,ZHANG Shu-qiong,XUE Wei. Contents and clinical significance of heme oxygenase-1 and unconjugated bilirubin in intracranial hematoma of cerebral hemorrhage patients[J]. Clinical Focus, 2009, 24(1) |
| |
| Authors: | LI Li LI Bo ZHANG Shu-qiong XUE Wei |
| |
| Affiliation: | LI Li,LI Bo,ZHANG Shu-qiong,XUE Wei Department of Neurology,Chongqing Three Gorges Central Hospital,Chongqing 404000,China |
| |
| Abstract: | Objective To investigate the content of heme oxygenase1(HO-1) and unconjugated bilirubin(UCB) in the intracranial hematoma.Methods Thirty patients of cerebral hemorrhage who had minimally invasive operation were enrolled,and the contents of HO-1 and UCB were detected in the first day,third day and sixth day after the operation by ELISA and oxidation of vanadate.Twenty healthy adults served as control group.And the volume of cerebral edema was measured in the sixth day.Results The contents of HO-1 and UCB in... |
| |
| Keywords: | cerebral hemorrhage surgical procedures minimally invasive heme oxygenase-1 bilirubin |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
