链霉素耳中毒遗传方式的研究

经对258名链霉素耳中毒患者及其亲属使用链霉素情况进行回顾性调查及群体分析表明:其一级亲属、二级亲属、三级亲属现患率分别为2.1448％、0.9748％、0.2059％。患者各级亲属现患率均高于新疆地区社会人群链霉素耳中毒现患率(0.0777％)。患者各级亲属的现惠率表现出随亲属级别降低现患率迅速下降的趋势。这些结果表明链霉素耳中毒未表现出单基因遗传病的遗传规律,而是符合多基因遗传病的特点。从多基因病的角度出发,作者计算了链霉素耳中毒遗传度为66％。

A Study on the Mode of Inheritance of the Streptomycin Ototoxicity

The condition of taking streptomycin of 258 streptomycin ototoxicity patients and their relatives was investigated. The incidences of the first, second and third degree relatives were 2.144 8%, 0.974 8% and 0.255 9% respectively. The incidence of a population of 30 896 persons was 0.077 7% According to the above data, it was proved that the streptomycin ototoxicity might beiong to the polygcnic inheritance. The heritability was 66%.