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Solid tumor screening recommendations in trisomy 18 |
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| Authors: | Shannon G. Farmakis Ann M. Barnes John C. Carey Stephen R. Braddock |
| Affiliation: | 1. https://orcid.org/0000-0002-0225-6291;2. Department of Radiology, Saint Louis University School of Medicine and SSM Health Cardinal Glennon Children's Hospital, St. Louis, Missouri;3. Shannon G. Farmakis, MD, Department of Radiology, Saint Louis University School of Medicine, 3635 Vista Avenue;4. St. Louis, MO 63110.;5. The Support Organization for Trisomy 18, 13 and Related Disorders, Rochester, New York;6. Department of Pediatrics, University of Utah, Salt Lake City, Utah;7. Division of Medical Genetics, Department of Pediatrics, Saint Louis University School of Medicine and SSM Cardinal Glennon Children's Hospital, St. Louis, Missouri |
| Abstract: | The purpose of this study was to determine whether trisomy 18 patients are at an increased risk of tumor development and require formal tumor screening recommendations. A literature search of trisomy 18 patients with reports of tumors or malignancies, and compilation of all previously reported as well as new unreported cases was performed. 67 patients with trisomy 18 were found to have documented malignancies. 44 patients had hepatoblastomas, 21 patients had Wilms tumors, one patient had a functional neurogenic neoplasia, and one patient had Hodgkins lymphoma. The increasing numbers of reported malignancies in patients with trisomy 18 supports the indication for an early screening process. Specific screening recommendations are outlined consisting of imaging exams and laboratory values performed at specific intervals. |
| Keywords: | hepatoblastoma risk screening trisomy 18 Wilms tumor |