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Treatment and outcomes in classic Hodgkin lymphoma post‐transplant lymphoproliferative disorder in children
Authors:Clare J. Twist  Susan M. Hiniker  Dita Gratzinger  Paulina M. Gutkin  David J. Merriott  Andrei Iagaru  Michael P. Link  Sarah S. Donaldson
Abstract:Classic Hodgkin lymphoma post‐transplant lymphoproliferative disorder (HL‐PTLD) has been rarely reported in children, with limited data available to guide treatment decisions. We report a retrospective review of five children diagnosed with classic HL‐PTLD following solid organ transplant between 2007 and 2013 at Stanford University. Patients were treated with Stanford V chemotherapy and involved field radiation therapy. With a median follow‐up of 7.2 years (range, 4.7–10.5 years) since diagnosis, all patients remain in remission from HL‐PTLD and free from graft failure. In this series, combined modality therapy with risk‐adapted chemotherapy and radiation therapy was a successful strategy for the treatment of classic HL‐PTLD.
Keywords:HL‐PTLD  pediatrics  radiation therapy  solid organ transplant
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