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Helminths products directly modulate T cells that mediate experimental autoimmune encephalomyelitis
Authors:Shauna M. Quinn  Mathilde Raverdeau  Aoife M. McGinley  Kingston H.G. Mills
Abstract:
Infection with helminths can protect against the development of autoimmune diseases and this has been associated with induction of anti‐inflammatory innate immune responses and Tregs. Here, we demonstrate that helminth‐derived products can directly target T cells, especially IL‐17‐secreting γδ T cells that play a key pathogenic role in CNS autoimmune disease.
Keywords:Experimental autoimmune encephalomyelitis  Fasciola hepatica  IL‐17  Th17  γ  δ    cell
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