Development and function of tissue resident macrophages in mice |
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| Institution: | 1. Centre for Molecular and Cellular Biology of Inflammation (CMCBI), King’s College London, London, UK;2. Institute of Neuropathology, University Freiburg, Freiburg, Germany;3. BIOSS Centre for Biological Signaling Studies, University of Freiburg, Freiburg, Germany;4. Immunology Program, Memorial Sloan Kettering Cancer Center, NY, NY, USA;5. Macrophages and Endothelial Cells group, Department of Developmental and Stem Cell Biology, CNRS UMR 3738, Institut Pasteur, Paris, France |
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| Abstract: | Macrophages are important for tissue development, homeostasis as well as immune response upon injury or infection. For a long time they were only seen as one uniform group of phagocytes with a common origin and similar functions. However, this view has been challenged in the last decade and revealed a complex diversity of tissue resident macrophages. Here, we want to present the current view on macrophage development and tissue specification and we will discuss differences as well as common patterns between heterogeneous macrophage subpopulations. |
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| Keywords: | Macrophage Erythro-myeloid progenitor Tissue specification Pulse labeling models Mononuclear phagocytes |
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