Prenatal exposure to phthalates and neuropsychological development during childhood |
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| Affiliation: | 1. Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain;2. CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain;3. Universitat Pompeu Fabra (UPF), Barcelona, Spain;4. Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA;5. Department of Genes and Environment, Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway;6. IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain;1. Department of Anatomy, School of Dentistry, Aichi Gakuin University, 1-100, Kusumoto-Cho, Chikusa-Ku, Nagoya, Aichi 464-8650, Japan;2. Department of Life Science, Kindai University, 3-4-1 Kowakae, Higashiosaka, Osaka 577-8502, Japan;1. Center for Environmental Research and Children''s Health (CERCH), School of Public Health, University of California Berkeley, Berkeley, CA 94720, USA;2. Division of Biostatistics, School of Public Health, University of California Berkeley, Berkeley, CA, USA;1. Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada;2. Behavioral Research Unit, Department of Paediatrics, University of Calgary, Calgary, Alberta, Canada;3. Alberta Children''s Hospital Research Institute for Child and Maternal Health, University of Calgary, Calgary, Alberta, Canada;1. Department of Maternal and Child Health Care, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China;2. Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China;3. Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China;4. Department of Psychological and Behavioral Development, Women and Children Healthcare Hospital, Liuzhou, Guangxi Zhuang Autonomous Region, PR China;5. Department of Epidemiology and Statistics, Beijing Municipal Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing, PR China;1. Department of Child Psychiatry, National Center for Child and Adolescent Psychiatry, Seoul National Hospital, Seoul, Republic of Korea;2. Department of Preventive Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea;3. Department of Nursing, Munkyung College, Munkyung, Republic of Korea;4. Department of Dental Hygiene, Yeongdong University, Yeongdong, Republic of Korea;5. Department of Occupational and Environmental Medicine, College of Medicine, Kyunghee University, Seoul, Republic of Korea;6. Department of Preventive Medicine, School of Medicine, Eulji University, Daejeon, Republic of Korea;7. Department of Preventive Medicine, School of Medicine, Dong-A University, Busan, Republic of Korea;8. Department of Occupational and Environmental Medicine, School of Medicine, Inha University, Incheon, Republic of Korea;9. Department of Information Statistics, College of Natural Science, Korean National Open University, Seoul, Republic of Korea;10. Department of Social and Preventive Medicine, School of Medicine, Sungkyunkwan University, Suwon, Republic of Korea;11. Department of Occupational and Environmental Medicine, Wonju Severance Christian Hospital, Wonju College of Medicine, Yonsei University, Wonju, Republic of Korea;12. Department of Preventive Medicine, School of Medicine, Kangwon National University, Chuncheon, Republic of Korea;13. Department of Preventive Medicine and Public Health, College of Medicine, Yeungnam University, Daegu, Republic of Korea;14. Department of Preventive Medicine, School of Medicine, Wonkwang University, Iksan, Republic of Korea;15. Department of Occupational and Environmental Medicine, School of Medicine, Chosun University, Gwangju, Republic of Korea;p. Department of Preventive Medicine, School of Medicine, Jeju National University, Jeju, Republic of Korea;q. Department of Environmental Epidemiology, Division of Environmental Health, National Institute of Environment, Incheon, Republic of Korea;1. Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA;2. Department of Epidemiology, Geisel School of Medicine, Dartmouth, Lebanon, NH, USA;3. Department of Biostatistics, Harvard T.H. Chan School of Public Health Boston, MA, USA;4. Department of Epidemiology, Harvard T.H. Chan School of Public Health Boston, MA, USA;5. National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA;6. Vincent Obstetrics and Gynecology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA;7. Department of Epidemiology, Brown University School of Public Health, Providence, RI, USA |
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| Abstract: | There is inconsistent evidence regarding the effects of prenatal phthalate exposure on children's neuropsychological development. We evaluate the association between prenatal phthalate exposure and the cognitive, psychomotor and behavioral development of 367 children at repeated ages in a prospective birth cohort study. We measured phthalate metabolites (sum of four DEHP metabolites – Σ4DEHP, MBzP, MEP, MiBP and MnBP) in urine samples collected during the 1st and 3rd trimesters of pregnancy in women participating in the INMA-Sabadell birth cohort study. We assessed cognitive and psychomotor development of their children at 1 and 4 years, and social competence, ADHD symptoms and other behavioral problems at 4 and 7 years. No associations were observed between prenatal phthalate exposure and cognitive and psychomotor scores at the age of 1 year and at the age of 4 years, except for an association between MBzP and lower psychomotor scores (β = −1.49 [95% confidence interval (CI) = −2.78, −0.21]). Σ4DEHP concentrations were associated with increased social competence scores at 4 years and with reduced ADHD symptoms at age 4 and 7 years. Increasing MEP concentrations were associated with a reduced risk of inattention symptoms at 4 years. No associations were observed for MBzP, MiBP or MnBP in relation to behavioral problems. This study, with multiple phthalate exposure measurements and measures of neuropsychological domains at different ages, suggest that prenatal phthalate exposure does not adversely affect children's cognitive, psychomotor or behavioral development. |
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